BAIT
CASK
CAGH39, CAMGUK, CMG, FGS4, LIN2, MICPCH, MRXSNA, TNRC8, RP11-540L11.1
calcium/calmodulin-dependent serine protein kinase (MAGUK family)
GO Process (7)
GO Function (2)
GO Component (11)
Gene Ontology Biological Process
- cell adhesion [TAS]
- extracellular matrix organization [TAS]
- negative regulation of cell-matrix adhesion [IMP]
- negative regulation of cellular response to growth factor stimulus [IMP]
- negative regulation of keratinocyte proliferation [IMP]
- negative regulation of wound healing [IMP]
- nucleotide phosphorylation [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
P2RX7
P2X7
purinergic receptor P2X, ligand-gated ion channel, 7
GO Process (21)
GO Function (7)
GO Component (6)
Gene Ontology Biological Process
- apoptotic signaling pathway [ISS]
- bleb assembly [IDA, ISS]
- cation transmembrane transport [IDA]
- cation transport [IDA]
- cell surface receptor signaling pathway [ISS]
- innate immune response [TAS]
- membrane depolarization [IDA]
- negative regulation of MAPK cascade [ISS]
- negative regulation of bone resorption [ISS]
- nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway [TAS]
- pore complex assembly [IDA]
- positive regulation of bone mineralization [ISS]
- positive regulation of calcium ion transport into cytosol [IDA]
- positive regulation of cytolysis [ISS]
- positive regulation of cytoskeleton organization [ISS]
- positive regulation of interleukin-1 beta secretion [IDA]
- purinergic nucleotide receptor signaling pathway [IDA]
- regulation of killing of cells of other organism [NAS]
- regulation of sodium ion transport [ISS]
- response to ATP [IDA]
- sensory perception of pain [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
Toward an understanding of the protein interaction network of the human liver.
Proteome-scale protein interaction maps are available for many organisms, ranging from bacteria, yeast, worms and flies to humans. These maps provide substantial new insights into systems biology, disease research and drug discovery. However, only a small fraction of the total number of human protein-protein interactions has been identified. In this study, we map the interactions of an unbiased selection of ... [more]
Mol. Syst. Biol. Oct. 13, 2011; 7(0);536 [Pubmed: 21988832]
Throughput
- High Throughput
Curated By
- BioGRID