BAIT
P2RX4
P2X4, P2X4R
purinergic receptor P2X, ligand-gated ion channel, 4
GO Process (23)
GO Function (8)
GO Component (8)
Gene Ontology Biological Process
- apoptotic signaling pathway [IDA]
- cation transmembrane transport [IDA]
- cellular response to ATP [IDA]
- endothelial cell activation [TAS]
- ion transmembrane transport [IDA]
- membrane depolarization [IDA]
- negative regulation of cardiac muscle hypertrophy [IMP]
- positive regulation of calcium ion transport [NAS]
- positive regulation of calcium ion transport into cytosol [IDA, IMP]
- positive regulation of calcium-mediated signaling [IDA, IMP]
- positive regulation of nitric oxide biosynthetic process [NAS]
- positive regulation of prostaglandin secretion [NAS]
- purinergic nucleotide receptor signaling pathway [IMP]
- regulation of blood pressure [IMP]
- regulation of cardiac muscle contraction [IMP]
- regulation of sodium ion transport [ISS]
- relaxation of cardiac muscle [IMP]
- response to ATP [IDA]
- response to fluid shear stress [IDA]
- sensory perception of pain [ISS]
- signal transduction [IDA]
- tissue homeostasis [NAS]
- transport [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
WNT4
SERKAL, WNT-4, RP1-224A6.7
wingless-type MMTV integration site family, member 4
GO Process (33)
GO Function (3)
GO Component (7)
Gene Ontology Biological Process
- adrenal gland development [IEP]
- androgen biosynthetic process [IDA]
- canonical Wnt signaling pathway [IDA]
- cell fate commitment [IBA]
- cellular response to transforming growth factor beta stimulus [IEP]
- epithelial to mesenchymal transition [IEP]
- establishment of protein localization to plasma membrane [IDA]
- female gonad development [ISS]
- female sex determination [IMP]
- kidney development [IEP]
- liver development [IEP]
- male gonad development [IEP, IMP]
- mammary gland epithelium development [IEP]
- metanephric mesenchymal cell differentiation [NAS]
- negative regulation of canonical Wnt signaling pathway [IDA]
- negative regulation of gene expression [IDA]
- negative regulation of male gonad development [IMP]
- negative regulation of steroid biosynthetic process [IDA]
- negative regulation of testicular blood vessel morphogenesis [IMP]
- negative regulation of testosterone biosynthetic process [IMP]
- negative regulation of transcription, DNA-templated [IMP, ISS]
- neuron differentiation [IBA]
- non-canonical Wnt signaling pathway via MAPK cascade [IDA]
- paramesonephric duct development [IMP]
- positive regulation of aldosterone biosynthetic process [IDA]
- positive regulation of bone mineralization [IDA]
- positive regulation of canonical Wnt signaling pathway [IDA]
- positive regulation of collagen biosynthetic process [IDA]
- positive regulation of cortisol biosynthetic process [IDA]
- positive regulation of dermatome development [IDA]
- positive regulation of osteoblast differentiation [IDA]
- positive regulation of transcription, DNA-templated [IDA, ISS]
- protein palmitoylation [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
Toward an understanding of the protein interaction network of the human liver.
Proteome-scale protein interaction maps are available for many organisms, ranging from bacteria, yeast, worms and flies to humans. These maps provide substantial new insights into systems biology, disease research and drug discovery. However, only a small fraction of the total number of human protein-protein interactions has been identified. In this study, we map the interactions of an unbiased selection of ... [more]
Mol. Syst. Biol. Oct. 13, 2011; 7(0);536 [Pubmed: 21988832]
Throughput
- High Throughput
Curated By
- BioGRID