CD74
Gene Ontology Biological Process
- T cell selection [NAS]
- antigen processing and presentation of endogenous antigen [NAS]
- antigen processing and presentation of exogenous peptide antigen via MHC class II [TAS]
- cell proliferation [IDA]
- immunoglobulin mediated immune response [ISS]
- intracellular protein transport [ISS]
- negative regulation of DNA damage response, signal transduction by p53 class mediator [IDA]
- negative regulation of apoptotic process [IDA]
- negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [IMP]
- negative regulation of peptide secretion [IDA]
- positive regulation of B cell proliferation [IMP]
- positive regulation of ERK1 and ERK2 cascade [IDA, IMP]
- positive regulation of chemokine (C-X-C motif) ligand 2 production [ISS]
- positive regulation of cytokine-mediated signaling pathway [IMP]
- positive regulation of fibroblast proliferation [IMP]
- positive regulation of macrophage cytokine production [ISS]
- positive regulation of neutrophil chemotaxis [ISS]
- positive regulation of peptidyl-tyrosine phosphorylation [IDA]
- prostaglandin biosynthetic process [IDA]
- protein complex assembly [ISS]
- regulation of macrophage activation [NAS]
- signal transduction [IDA]
Gene Ontology Molecular Function- MHC class II protein binding [ISS, NAS]
- MHC class II protein binding, via antigen binding groove [IDA]
- MHC class II protein complex binding [IDA]
- beta-amyloid binding [IPI]
- cytokine binding [IPI]
- cytokine receptor activity [IDA]
- identical protein binding [TAS]
- macrophage migration inhibitory factor binding [IPI]
- protein binding [IPI]
- protein binding involved in protein folding [IDA]
- MHC class II protein binding [ISS, NAS]
- MHC class II protein binding, via antigen binding groove [IDA]
- MHC class II protein complex binding [IDA]
- beta-amyloid binding [IPI]
- cytokine binding [IPI]
- cytokine receptor activity [IDA]
- identical protein binding [TAS]
- macrophage migration inhibitory factor binding [IPI]
- protein binding [IPI]
- protein binding involved in protein folding [IDA]
Gene Ontology Cellular Component
- ER to Golgi transport vesicle membrane [TAS]
- Golgi membrane [TAS]
- MHC class II protein complex [ISS]
- cell surface [IDA]
- clathrin-coated endocytic vesicle membrane [TAS]
- endocytic vesicle membrane [TAS]
- extracellular vesicular exosome [IDA]
- integral component of lumenal side of endoplasmic reticulum membrane [TAS]
- integral component of membrane [IDA]
- intracellular [TAS]
- lysosomal lumen [TAS]
- lysosomal membrane [TAS]
- macrophage migration inhibitory factor receptor complex [IDA]
- membrane [IDA]
- plasma membrane [TAS]
- trans-Golgi network membrane [TAS]
- transport vesicle membrane [TAS]
- vacuole [IDA]
HADHA
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
Toward an understanding of the protein interaction network of the human liver.
Proteome-scale protein interaction maps are available for many organisms, ranging from bacteria, yeast, worms and flies to humans. These maps provide substantial new insights into systems biology, disease research and drug discovery. However, only a small fraction of the total number of human protein-protein interactions has been identified. In this study, we map the interactions of an unbiased selection of ... [more]
Throughput
- High Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| CD74 HADHA | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | - | BioGRID | - |
Curated By
- BioGRID