BAIT
EPS8
DFNB102
epidermal growth factor receptor pathway substrate 8
GO Process (13)
GO Function (4)
GO Component (5)
Gene Ontology Biological Process
- Rac protein signal transduction [ISS]
- actin crosslink formation [ISS]
- actin filament bundle assembly [ISS]
- actin polymerization-dependent cell motility [ISS]
- barbed-end actin filament capping [ISS]
- cell proliferation [TAS]
- dendritic cell migration [ISS]
- epidermal growth factor receptor signaling pathway [TAS]
- exit from mitosis [ISS]
- positive regulation of signal transduction [TAS]
- regulation of actin filament length [ISS]
- regulation of cell shape [ISS]
- signal transduction [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
NACC2
BEND9, BTBD14, BTBD14A, BTBD31, NAC-2, RBB
NACC family member 2, BEN and BTB (POZ) domain containing
GO Process (10)
GO Function (7)
GO Component (4)
Gene Ontology Biological Process
- cellular protein complex localization [IDA]
- histone deacetylation [IDA]
- negative regulation of G1/S transition of mitotic cell cycle by negative regulation of transcription from RNA polymerase II promoter [IDA]
- negative regulation of cell proliferation [IDA]
- negative regulation of transcription, DNA-templated [IDA, ISS]
- positive regulation of cell proliferation [ISS]
- positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage [IDA]
- posttranscriptional regulation of gene expression [IMP]
- protein homooligomerization [IDA, ISS]
- transcription from RNA polymerase II promoter [IDA]
Gene Ontology Molecular Function- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription [IDA]
- RNA polymerase II transcription factor binding transcription factor activity [IDA]
- histone deacetylase activity [IDA]
- histone deacetylase binding [IPI]
- protein binding [IPI]
- protein homodimerization activity [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription [IDA]
- RNA polymerase II transcription factor binding transcription factor activity [IDA]
- histone deacetylase activity [IDA]
- histone deacetylase binding [IPI]
- protein binding [IPI]
- protein homodimerization activity [IDA]
Gene Ontology Cellular Component
Homo sapiens
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
Toward an understanding of the protein interaction network of the human liver.
Proteome-scale protein interaction maps are available for many organisms, ranging from bacteria, yeast, worms and flies to humans. These maps provide substantial new insights into systems biology, disease research and drug discovery. However, only a small fraction of the total number of human protein-protein interactions has been identified. In this study, we map the interactions of an unbiased selection of ... [more]
Mol. Syst. Biol. Oct. 13, 2011; 7(0);536 [Pubmed: 21988832]
Throughput
- High Throughput
Curated By
- BioGRID