BAIT
YAP1
AI325207, Yap, Yap65, Yki, Yorkie
yes-associated protein 1
GO Process (30)
GO Function (9)
GO Component (7)
Gene Ontology Biological Process
- cell morphogenesis [IMP]
- cell proliferation [ISO]
- cellular response to DNA damage stimulus [ISO]
- cellular response to gamma radiation [ISO]
- cellular response to retinoic acid [IDA]
- contact inhibition [ISO]
- embryonic heart tube morphogenesis [IGI]
- hippo signaling [IGI]
- keratinocyte differentiation [IGI, IMP]
- lateral mesoderm development [IGI]
- negative regulation of epithelial cell differentiation [IDA]
- negative regulation of extrinsic apoptotic signaling pathway [IGI]
- negative regulation of nucleic acid-templated transcription [ISO]
- negative regulation of stem cell differentiation [IDA]
- notochord development [IGI]
- paraxial mesoderm development [IGI]
- positive regulation of canonical Wnt signaling pathway [IDA]
- positive regulation of cell proliferation [IDA, IMP]
- positive regulation of organ growth [IDA]
- positive regulation of stem cell maintenance [IMP]
- positive regulation of transcription from RNA polymerase II promoter [IDA, IGI]
- regulation of canonical Wnt signaling pathway [IGI]
- regulation of cell proliferation [IGI]
- regulation of keratinocyte proliferation [IMP]
- regulation of metanephric nephron tubule epithelial cell differentiation [IGI]
- regulation of stem cell proliferation [IDA, IMP]
- regulation of transcription from RNA polymerase II promoter [IPI]
- somatic stem cell maintenance [IDA]
- transcription from RNA polymerase II promoter [IPI]
- vasculogenesis [IMP]
Gene Ontology Molecular Function- RNA polymerase II core promoter sequence-specific DNA binding [IDA]
- RNA polymerase II transcription factor binding transcription factor activity [IPI]
- chromatin binding [IDA]
- proline-rich region binding [IPI]
- protein C-terminus binding [IPI]
- protein binding [IPI]
- transcription coactivator activity [IDA, ISO]
- transcription corepressor activity [ISO]
- transcription regulatory region DNA binding [ISO]
- RNA polymerase II core promoter sequence-specific DNA binding [IDA]
- RNA polymerase II transcription factor binding transcription factor activity [IPI]
- chromatin binding [IDA]
- proline-rich region binding [IPI]
- protein C-terminus binding [IPI]
- protein binding [IPI]
- transcription coactivator activity [IDA, ISO]
- transcription corepressor activity [ISO]
- transcription regulatory region DNA binding [ISO]
Mus musculus
PREY
YWHAB
GW128, HEL-S-1, HS1, KCIP-1, YWHAA, RP1-148E22.1
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta
GO Process (22)
GO Function (6)
GO Component (7)
Gene Ontology Biological Process
- Fc-epsilon receptor signaling pathway [TAS]
- MAPK cascade [TAS]
- RNA metabolic process [TAS]
- Ras protein signal transduction [TAS]
- activation of MAPKK activity [TAS]
- apoptotic process [TAS]
- axon guidance [TAS]
- cytoplasmic sequestering of protein [IDA]
- epidermal growth factor receptor signaling pathway [TAS]
- fibroblast growth factor receptor signaling pathway [TAS]
- gene expression [TAS]
- hippo signaling [TAS]
- innate immune response [TAS]
- insulin receptor signaling pathway [TAS]
- intrinsic apoptotic signaling pathway [TAS]
- mRNA metabolic process [TAS]
- membrane organization [TAS]
- negative regulation of protein dephosphorylation [IDA]
- neurotrophin TRK receptor signaling pathway [TAS]
- positive regulation of catalytic activity [IDA]
- positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway [TAS]
- small GTPase mediated signal transduction [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
The Crumbs complex couples cell density sensing to Hippo-dependent control of the TGF-β-SMAD pathway.
The Hippo pathway senses cell density information to control tissue growth by regulating the localization of the transcriptional regulators TAZ and YAP (TAZ/YAP). TAZ/YAP also regulate TGF-β-SMAD signaling, but whether this role is linked to cell density sensing is unknown. Here we demonstrate that TAZ/YAP dictate the localization of active SMAD complexes in response to cell density-mediated formation of polarity ... [more]
Dev. Cell Dec. 14, 2010; 19(6);831-44 [Pubmed: 21145499]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| YAP1 YWHAB | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | - | BioGRID | 1462990 |
Curated By
- BioGRID