EDNRA
Gene Ontology Biological Process
- G-protein coupled receptor signaling pathway [NAS]
- activation of adenylate cyclase activity [TAS]
- activation of phospholipase C activity [TAS]
- artery smooth muscle contraction [IMP]
- cell proliferation [NAS]
- endothelin receptor signaling pathway [NAS]
- glucose transport [ISS]
- metabolic process [TAS]
- positive regulation of cytosolic calcium ion concentration [TAS]
- respiratory gaseous exchange [ISS]
- signal transduction [TAS]
- smooth muscle contraction [NAS]
- vasoconstriction [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
EDN1
Gene Ontology Biological Process
- G-protein coupled receptor signaling pathway [IDA]
- artery smooth muscle contraction [IDA, TAS]
- calcium-mediated signaling [IDA]
- cell surface receptor signaling pathway [IDA]
- cell-cell signaling [IDA]
- inositol phosphate-mediated signaling [IDA]
- leukocyte activation [TAS]
- negative regulation of blood coagulation [TAS]
- negative regulation of cellular protein metabolic process [IDA]
- negative regulation of nitric-oxide synthase biosynthetic process [IDA]
- negative regulation of transcription from RNA polymerase II promoter [IDA]
- neutrophil chemotaxis [IDA]
- nitric oxide transport [IDA]
- peptide hormone secretion [IDA]
- phosphatidylinositol 3-kinase signaling [IDA]
- positive regulation of JUN kinase activity [IDA]
- positive regulation of MAP kinase activity [IDA]
- positive regulation of cardiac muscle hypertrophy [IDA]
- positive regulation of cell migration [IDA]
- positive regulation of cell proliferation [IDA]
- positive regulation of cell size [IDA]
- positive regulation of chemokine-mediated signaling pathway [IC]
- positive regulation of cytosolic calcium ion concentration [IDA]
- positive regulation of endothelial cell migration [TAS]
- positive regulation of heart rate [IDA]
- positive regulation of hormone secretion [IDA]
- positive regulation of mitosis [IDA]
- positive regulation of nitric oxide biosynthetic process [TAS]
- positive regulation of prostaglandin-endoperoxide synthase activity [IMP]
- positive regulation of receptor biosynthetic process [IDA]
- positive regulation of sarcomere organization [IMP]
- positive regulation of smooth muscle cell proliferation [IDA]
- prostaglandin biosynthetic process [IDA]
- protein kinase C deactivation [IDA]
- regulation of systemic arterial blood pressure by endothelin [IDA]
- vasoconstriction [IDA]
- vein smooth muscle contraction [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Reconstituted Complex
An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator.
Publication
The ligand-receptor interactions of the endothelin systems are mediated by distinct "message" and "address" domains.
Pharmacologic responses to endothelins (ETs) are mediated by two subtypes of G-protein-coupled receptors, termed ETA and ETB. A chimeric receptor that has the transmembrane domains (TMDs) IV-VI with the adjacent loop regions from ETB embedded in the remaining regions from ETA exhibits specific binding to the N-terminally truncated ETB agonists 125I-BQ3020 and 125I-IRL1620, to the same level as that of ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID