REN
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
AGT
Gene Ontology Biological Process
- G-protein coupled receptor signaling pathway [IDA]
- G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger [TAS]
- angiotensin maturation [TAS]
- blood vessel remodeling [TAS]
- cell-cell signaling [TAS]
- cellular lipid metabolic process [TAS]
- cellular protein metabolic process [TAS]
- kidney development [IMP]
- low-density lipoprotein particle remodeling [NAS]
- negative regulation of endopeptidase activity [IBA]
- negative regulation of neurotrophin TRK receptor signaling pathway [IDA]
- negative regulation of sodium ion transmembrane transporter activity [TAS]
- nitric oxide mediated signal transduction [TAS]
- phospholipase C-activating G-protein coupled receptor signaling pathway [NAS]
- positive regulation of NAD(P)H oxidase activity [TAS]
- positive regulation of NF-kappaB transcription factor activity [TAS]
- positive regulation of activation of JAK2 kinase activity [IMP]
- positive regulation of branching involved in ureteric bud morphogenesis [IDA]
- positive regulation of cardiac muscle hypertrophy [ISS]
- positive regulation of cellular protein metabolic process [IDA]
- positive regulation of cholesterol esterification [IDA]
- positive regulation of cytokine production [TAS]
- positive regulation of endothelial cell migration [IDA]
- positive regulation of epidermal growth factor receptor signaling pathway [IDA]
- positive regulation of extrinsic apoptotic signaling pathway [IDA]
- positive regulation of fibroblast proliferation [ISS]
- positive regulation of inflammatory response [TAS]
- positive regulation of macrophage derived foam cell differentiation [IC]
- positive regulation of peptidyl-tyrosine phosphorylation [IDA]
- positive regulation of phosphatidylinositol 3-kinase signaling [IDA]
- positive regulation of protein tyrosine kinase activity [IMP]
- positive regulation of reactive oxygen species metabolic process [TAS]
- positive regulation of transcription, DNA-templated [IDA]
- regulation of blood vessel size by renin-angiotensin [TAS]
- regulation of blood volume by renin-angiotensin [NAS]
- regulation of cell growth [NAS]
- regulation of cell proliferation [NAS]
- regulation of proteolysis [IBA]
- regulation of renal output by angiotensin [NAS]
- regulation of renal sodium excretion [NAS]
- regulation of vasoconstriction [NAS]
- renal system process [IDA]
- renin-angiotensin regulation of aldosterone production [NAS]
- response to muscle activity involved in regulation of muscle adaptation [ISS]
- small molecule metabolic process [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Biochemical Activity (Proteolytic Processing)
An interaction is inferred from the biochemical effect of one protein upon another, for example, GTP-GDP exchange activity or phosphorylation of a substrate by a kinase. The bait protein executes the activity on the substrate hit protein. A Modification value is recorded for interactions of this type with the possible values Phosphorylation, Ubiquitination, Sumoylation, Dephosphorylation, Methylation, Prenylation, Acetylation, Deubiquitination, Proteolytic Processing, Glucosylation, Nedd(Rub1)ylation, Deacetylation, No Modification, Demethylation.
Publication
Pivotal role of the renin/prorenin receptor in angiotensin II production and cellular responses to renin.
Renin is an aspartyl protease essential for the control of blood pressure and was long suspected to have cellular receptors. We report the expression cloning of the human renin receptor complementary DNA encoding a 350-amino acid protein with a single transmembrane domain and no homology with any known membrane protein. Transfected cells stably expressing the receptor showed renin- and prorenin-specific ... [more]
Throughput
- Low Throughput
Additional Notes
- Activity of renin on angiotensinogen was greater when renin was membrane-associated (through receptor)
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| AGT REN | Biochemical Activity Biochemical Activity An interaction is inferred from the biochemical effect of one protein upon another, for example, GTP-GDP exchange activity or phosphorylation of a substrate by a kinase. The bait protein executes the activity on the substrate hit protein. A Modification value is recorded for interactions of this type with the possible values Phosphorylation, Ubiquitination, Sumoylation, Dephosphorylation, Methylation, Prenylation, Acetylation, Deubiquitination, Proteolytic Processing, Glucosylation, Nedd(Rub1)ylation, Deacetylation, No Modification, Demethylation. | Low | - | BioGRID | 908528 | |
| AGT REN | Co-crystal Structure Co-crystal Structure Interaction directly demonstrated at the atomic level by X-ray crystallography. Also used for NMR or Electron Microscopy (EM) structures. If there is no obvious bait-hit directionality to the interaction involving 3 or more proteins, then the co-crystallized proteins should be listed as a complex. | Low | - | BioGRID | - |
Curated By
- BioGRID