BAIT
EGFL7
NEU1, VE-STATIN, ZNEU1, RP11-251M1.2
EGF-like-domain, multiple 7
GO Process (4)
GO Function (0)
GO Component (2)
Gene Ontology Biological Process
Gene Ontology Cellular Component
Homo sapiens
PREY
NOTCH4
INT3, DAQB-143M3.4
notch 4
GO Process (15)
GO Function (4)
GO Component (9)
Gene Ontology Biological Process
- Notch receptor processing [TAS]
- Notch signaling pathway [TAS]
- cell differentiation [NAS]
- cell fate determination [TAS]
- embryo development [ISS]
- gene expression [TAS]
- hemopoiesis [TAS]
- mammary gland development [IDA]
- morphogenesis of a branching structure [ISS]
- negative regulation of cell differentiation [NAS]
- negative regulation of endothelial cell differentiation [ISS]
- patterning of blood vessels [ISS]
- positive regulation of transcription of Notch receptor target [TAS]
- positive regulation of transcription, DNA-templated [TAS]
- transcription initiation from RNA polymerase II promoter [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
Epidermal growth factor-like domain 7 (EGFL7) modulates Notch signalling and affects neural stem cell renewal.
Epidermal growth factor-like domain 7 (EGFL7) is a secreted factor implicated in cellular responses such as cell migration and blood vessel formation; however the molecular mechanisms underlying the effects of EGFL7 are largely unknown. Here we have identified transmembrane receptors of the Notch family as EGFL7-binding molecules. Secreted EGFL7 binds to a region in Notch involved in ligand-mediated receptor activation, ... [more]
Nat. Cell Biol. Jul. 01, 2009; 11(7);873-80 [Pubmed: 19503073]
Throughput
- Low Throughput
Curated By
- BioGRID