PTGIR
Gene Ontology Biological Process
- G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger [TAS]
- adenylate cyclase-activating G-protein coupled receptor signaling pathway [IMP]
- blood coagulation [TAS]
- cell-cell signaling [TAS]
- negative regulation of platelet-derived growth factor receptor signaling pathway [ISS]
- negative regulation of smooth muscle cell proliferation [IDA]
- positive regulation of GTPase activity [TAS]
- positive regulation of cAMP biosynthetic process [IMP]
- positive regulation of cAMP-mediated signaling [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
PDZD3
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Co-localization
Interaction inferred from two proteins that co-localize in the cell by indirect immunofluorescence only when in addition, if one gene is deleted, the other protein becomes mis-localized. Also includes co-dependent association of proteins with promoter DNA in chromatin immunoprecipitation experiments.
Publication
Interaction of the human prostacyclin receptor and the NHERF4 family member intestinal and kidney enriched PDZ protein (IKEPP).
Prostacyclin and its I prostanoid receptor, the IP, play central roles in hemostasis and in re-endothelialization in response to vascular injury. Herein, intestinal and kidney enriched PDZ protein (IKEPP) was identified as an interactant of the human (h) IP mediated through binding of PDZ domain 1 (PDZ(D1)) and, to a lesser extent, PDZ(D2) of IKEPP to a carboxyl-terminal Class I ... [more]
Throughput
- Low Throughput
Ontology Terms
- plasma membrane (GO:0005886)
- perinuclear region of cytoplasm (GO:0048471)
- huvec cell (BTO:0001949)
- umbilical vein (UBERON:0002066)
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| PTGIR PDZD3 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | 906264 | |
| PTGIR PDZD3 | Two-hybrid Two-hybrid Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation. | Low | - | BioGRID | 906240 |
Curated By
- BioGRID