BAIT
BMPR2
BMPR-II, BMPR3, BMR2, BRK-3, POVD1, PPH1, T-ALK
bone morphogenetic protein receptor, type II (serine/threonine kinase)
GO Process (30)
GO Function (2)
GO Component (5)
Gene Ontology Biological Process
- BMP signaling pathway [IDA, IMP, ISS, TAS]
- activin receptor signaling pathway [TAS]
- anterior/posterior pattern specification [ISS]
- artery development [ISS]
- blood vessel remodeling [ISS]
- cellular response to starvation [IEP]
- chondrocyte development [IMP]
- lung alveolus development [ISS]
- lymphangiogenesis [ISS]
- lymphatic endothelial cell differentiation [ISS]
- mesoderm formation [ISS]
- negative regulation of DNA biosynthetic process [IMP]
- negative regulation of cell growth [IDA]
- negative regulation of chondrocyte proliferation [IMP]
- negative regulation of systemic arterial blood pressure [IMP]
- negative regulation of vasoconstriction [ISS]
- positive regulation of BMP signaling pathway [IMP]
- positive regulation of bone mineralization [IMP]
- positive regulation of endothelial cell migration [IMP]
- positive regulation of endothelial cell proliferation [IMP]
- positive regulation of epithelial cell migration [IDA]
- positive regulation of osteoblast differentiation [IMP]
- positive regulation of pathway-restricted SMAD protein phosphorylation [IMP]
- regulation of cell proliferation [IMP]
- regulation of lung blood pressure [IMP, ISS]
- retina vasculature development in camera-type eye [ISS]
- transcription from RNA polymerase II promoter [IMP]
- transmembrane receptor protein serine/threonine kinase signaling pathway [IDA]
- vascular endothelial growth factor receptor signaling pathway [ISS]
- venous blood vessel development [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
BMP10
bone morphogenetic protein 10
GO Process (26)
GO Function (6)
GO Component (5)
Gene Ontology Biological Process
- BMP signaling pathway [IDA]
- SMAD protein signal transduction [IBA]
- activin receptor signaling pathway [IDA]
- adult heart development [ISS]
- atrial cardiac muscle tissue morphogenesis [ISS]
- cardiac muscle cell proliferation [ISS]
- extracellular matrix organization [TAS]
- heart trabecula formation [ISS]
- negative regulation of cardiac muscle hypertrophy [ISS]
- negative regulation of cell growth [IDA]
- negative regulation of cell migration [IDA]
- negative regulation of endothelial cell migration [IDA]
- pathway-restricted SMAD protein phosphorylation [IDA]
- positive regulation of cardiac muscle cell proliferation [ISS]
- positive regulation of cardiac muscle hypertrophy [IMP]
- positive regulation of cell proliferation involved in heart morphogenesis [ISS]
- positive regulation of pathway-restricted SMAD protein phosphorylation [IDA]
- positive regulation of sarcomere organization [IDA]
- positive regulation of transcription, DNA-templated [IDA]
- regulation of MAPK cascade [IBA]
- regulation of apoptotic process [IBA]
- regulation of cardiac muscle contraction [IMP]
- regulation of cardiac muscle hypertrophy in response to stress [IDA]
- sarcomere organization [ISS]
- ventricular cardiac muscle cell development [ISS]
- ventricular cardiac muscle tissue morphogenesis [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Reconstituted Complex
An interaction is detected between purified proteins in vitro.
Publication
Specificity and structure of a high affinity activin receptor-like kinase 1 (ALK1) signaling complex.
Activin receptor-like kinase 1 (ALK1), an endothelial cell-specific type I receptor of the TGF-β superfamily, is an important regulator of normal blood vessel development as well as pathological tumor angiogenesis. As such, ALK1 is an important therapeutic target. Thus, several ALK1-directed agents are currently in clinical trials as anti-angiogenic cancer therapeutics. Given the biological and clinical importance of the ALK1 ... [more]
J. Biol. Chem. Aug. 10, 2012; 287(33);27313-25 [Pubmed: 22718755]
Throughput
- Low Throughput
Curated By
- BioGRID