BMPR2
Gene Ontology Biological Process
- BMP signaling pathway [IDA, IMP, ISS, TAS]
- activin receptor signaling pathway [TAS]
- anterior/posterior pattern specification [ISS]
- artery development [ISS]
- blood vessel remodeling [ISS]
- cellular response to starvation [IEP]
- chondrocyte development [IMP]
- lung alveolus development [ISS]
- lymphangiogenesis [ISS]
- lymphatic endothelial cell differentiation [ISS]
- mesoderm formation [ISS]
- negative regulation of DNA biosynthetic process [IMP]
- negative regulation of cell growth [IDA]
- negative regulation of chondrocyte proliferation [IMP]
- negative regulation of systemic arterial blood pressure [IMP]
- negative regulation of vasoconstriction [ISS]
- positive regulation of BMP signaling pathway [IMP]
- positive regulation of bone mineralization [IMP]
- positive regulation of endothelial cell migration [IMP]
- positive regulation of endothelial cell proliferation [IMP]
- positive regulation of epithelial cell migration [IDA]
- positive regulation of osteoblast differentiation [IMP]
- positive regulation of pathway-restricted SMAD protein phosphorylation [IMP]
- regulation of cell proliferation [IMP]
- regulation of lung blood pressure [IMP, ISS]
- retina vasculature development in camera-type eye [ISS]
- transcription from RNA polymerase II promoter [IMP]
- transmembrane receptor protein serine/threonine kinase signaling pathway [IDA]
- vascular endothelial growth factor receptor signaling pathway [ISS]
- venous blood vessel development [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
BMP10
Gene Ontology Biological Process
- BMP signaling pathway [IDA]
- SMAD protein signal transduction [IBA]
- activin receptor signaling pathway [IDA]
- adult heart development [ISS]
- atrial cardiac muscle tissue morphogenesis [ISS]
- cardiac muscle cell proliferation [ISS]
- extracellular matrix organization [TAS]
- heart trabecula formation [ISS]
- negative regulation of cardiac muscle hypertrophy [ISS]
- negative regulation of cell growth [IDA]
- negative regulation of cell migration [IDA]
- negative regulation of endothelial cell migration [IDA]
- pathway-restricted SMAD protein phosphorylation [IDA]
- positive regulation of cardiac muscle cell proliferation [ISS]
- positive regulation of cardiac muscle hypertrophy [IMP]
- positive regulation of cell proliferation involved in heart morphogenesis [ISS]
- positive regulation of pathway-restricted SMAD protein phosphorylation [IDA]
- positive regulation of sarcomere organization [IDA]
- positive regulation of transcription, DNA-templated [IDA]
- regulation of MAPK cascade [IBA]
- regulation of apoptotic process [IBA]
- regulation of cardiac muscle contraction [IMP]
- regulation of cardiac muscle hypertrophy in response to stress [IDA]
- sarcomere organization [ISS]
- ventricular cardiac muscle cell development [ISS]
- ventricular cardiac muscle tissue morphogenesis [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Reconstituted Complex
An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator.
Publication
Specificity and structure of a high affinity activin receptor-like kinase 1 (ALK1) signaling complex.
Activin receptor-like kinase 1 (ALK1), an endothelial cell-specific type I receptor of the TGF-β superfamily, is an important regulator of normal blood vessel development as well as pathological tumor angiogenesis. As such, ALK1 is an important therapeutic target. Thus, several ALK1-directed agents are currently in clinical trials as anti-angiogenic cancer therapeutics. Given the biological and clinical importance of the ALK1 ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID