SLT2
Gene Ontology Biological Process
- UFP-specific transcription factor mRNA processing involved in endoplasmic reticulum unfolded protein response [IMP]
- barrier septum assembly [IGI]
- endoplasmic reticulum unfolded protein response [IDA, IMP]
- fungal-type cell wall biogenesis [IGI]
- peroxisome degradation [IMP]
- protein phosphorylation [IDA, IMP]
- regulation of cell size [IMP]
- regulation of fungal-type cell wall organization [IGI, IMP]
- regulation of transcription factor import into nucleus [IMP]
- response to acidic pH [IMP]
- signal transduction [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
STE20
Gene Ontology Biological Process
- activation of MAPKKK activity [IDA]
- bipolar cellular bud site selection [IGI, IMP]
- budding cell apical bud growth [IGI, IMP]
- cellular bud site selection [IMP]
- cellular response to heat [IMP]
- invasive growth in response to glucose limitation [IMP]
- negative regulation of gene expression [IGI, IMP]
- osmosensory signaling pathway via Sho1 osmosensor [IGI, IMP]
- pheromone-dependent signal transduction involved in conjugation with cellular fusion [IGI, IMP]
- positive regulation of apoptotic process [IMP]
- protein phosphorylation [IDA]
- pseudohyphal growth [IMP]
- regulation of exit from mitosis [IMP]
- signal transduction involved in filamentous growth [IMP]
- sterol import [IMP]
- stress granule assembly [IGI, IMP]
- vacuole inheritance [IGI, IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Dosage Growth Defect
A genetic interaction is inferred when over expression or increased dosage of one gene causes a growth defect in a strain that is mutated or deleted for another gene.
Publication
Functional wiring of the yeast kinome revealed by global analysis of genetic network motifs.
A combinatorial genetic perturbation strategy was applied to interrogate the yeast kinome on a genome-wide scale. We assessed the global effects of gene overexpression or gene deletion to map an integrated genetic interaction network of synthetic dosage lethal (SDL) and loss-of-function genetic interactions (GIs) for 92 kinases, producing a meta-network of 8700 GIs enriched for pathways known to be regulated ... [more]
Quantitative Score
- -0.76 [SGA Score]
Throughput
- High Throughput
Ontology Terms
- phenotype: vegetative growth (APO:0000106)
- phenotype: colony size (APO:0000063)
Additional Notes
- score threshold >=0.2=<
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| STE20 SLT2 | Biochemical Activity Biochemical Activity An interaction is inferred from the biochemical effect of one protein upon another, for example, GTP-GDP exchange activity or phosphorylation of a substrate by a kinase. The bait protein executes the activity on the substrate hit protein. A Modification value is recorded for interactions of this type with the possible values Phosphorylation, Ubiquitination, Sumoylation, Dephosphorylation, Methylation, Prenylation, Acetylation, Deubiquitination, Proteolytic Processing, Glucosylation, Nedd(Rub1)ylation, Deacetylation, No Modification, Demethylation. | Low | - | BioGRID | 251914 | |
| STE20 SLT2 | Negative Genetic Negative Genetic Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores. | High | -3.3969 | BioGRID | 321974 |
Curated By
- BioGRID