PTK2
Gene Ontology Biological Process
Gene Ontology Molecular Function
DEP1
Gene Ontology Biological Process
- histone deacetylation [IMP]
- negative regulation of chromatin silencing at rDNA [IMP]
- negative regulation of chromatin silencing at silent mating-type cassette [IMP]
- negative regulation of chromatin silencing at telomere [IDA, IGI, IMP]
- negative regulation of inositol biosynthetic process by negative regulation of transcription from RNA polymerase II promoter [IMP]
- negative regulation of phosphatidylcholine biosynthetic process by negative regulation of transcription from RNA polymerase II promoter [IMP]
- negative regulation of phosphatidylserine biosynthetic process by negative regulation of transcription from RNA polymerase II promoter [IMP]
- negative regulation of transcription from RNA polymerase II promoter [IMP]
- positive regulation of inositol biosynthetic process by positive regulation of transcription from RNA polymerase II promoter [IMP]
- positive regulation of phosphatidylcholine biosynthetic process by positive regulation of transcription from RNA polymerase II promoter [IMP]
- positive regulation of phosphatidylserine biosynthetic process by positive regulation of transcription from RNA polymerase II promoter [IMP]
- positive regulation of transcription from RNA polymerase II promoter [IMP]
- positive regulation of transcription from RNA polymerase II promoter in response to heat stress [IMP]
- regulation of DNA-dependent DNA replication initiation [IMP]
- regulation of transcription from RNA polymerase II promoter [IMP]
Gene Ontology Cellular Component
Negative Genetic
Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores.
Publication
Functional wiring of the yeast kinome revealed by global analysis of genetic network motifs.
A combinatorial genetic perturbation strategy was applied to interrogate the yeast kinome on a genome-wide scale. We assessed the global effects of gene overexpression or gene deletion to map an integrated genetic interaction network of synthetic dosage lethal (SDL) and loss-of-function genetic interactions (GIs) for 92 kinases, producing a meta-network of 8700 GIs enriched for pathways known to be regulated ... [more]
Quantitative Score
- -0.276 [SGA Score]
Throughput
- High Throughput
Ontology Terms
- phenotype: vegetative growth (APO:0000106)
- phenotype: colony size (APO:0000063)
Additional Notes
- score threshold <= -0.12, interaction detected by Synthetic Genetic Array (SGA)
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| PTK2 DEP1 | Negative Genetic Negative Genetic Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores. | High | -0.2295 | BioGRID | 2139003 |
Curated By
- BioGRID