ELM1
Gene Ontology Biological Process
- axial cellular bud site selection [TAS]
- budding cell bud growth [IMP]
- cell morphogenesis [IMP]
- cytokinesis checkpoint [TAS]
- glucose metabolic process [IGI, IMP]
- positive regulation of protein autophosphorylation [IDA, IMP]
- protein autophosphorylation [IDA, IMP]
- protein phosphorylation [IDA, IGI]
- pseudohyphal growth [IMP]
- response to drug [IMP]
- response to osmotic stress [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
UME6
Gene Ontology Biological Process
- chromatin remodeling [IMP]
- lipid particle organization [IMP]
- negative regulation of inositol biosynthetic process by negative regulation of transcription from RNA polymerase II promoter [IMP]
- negative regulation of transcription from RNA polymerase II promoter during meiosis [IMP]
- negative regulation of transcription from RNA polymerase II promoter during mitosis [IMP]
- nitrogen catabolite repression of transcription from RNA polymerase II promoter [IMP]
- positive regulation of meiosis by negative regulation of transcription from RNA polymerase II promoter [IMP]
- positive regulation of meiosis by positive regulation of transcription from RNA polymerase II promoter [IMP]
- positive regulation of phosphatidylcholine biosynthetic process by positive regulation of transcription from RNA polymerase II promoter [IMP]
- positive regulation of phosphatidylserine biosynthetic process by positive regulation of transcription from RNA polymerase II promoter [IMP]
- positive regulation of transcription from RNA polymerase II promoter during meiosis [IMP]
- pseudohyphal growth [IMP]
- spore germination [IMP]
Gene Ontology Molecular Function- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription [IDA, IMP]
- repressing transcription factor binding [IDA, IPI]
- sequence-specific DNA binding [IDA]
- transcription factor binding transcription factor activity [IGI]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription [IDA, IMP]
- repressing transcription factor binding [IDA, IPI]
- sequence-specific DNA binding [IDA]
- transcription factor binding transcription factor activity [IGI]
Gene Ontology Cellular Component
Negative Genetic
Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores.
Publication
Functional wiring of the yeast kinome revealed by global analysis of genetic network motifs.
A combinatorial genetic perturbation strategy was applied to interrogate the yeast kinome on a genome-wide scale. We assessed the global effects of gene overexpression or gene deletion to map an integrated genetic interaction network of synthetic dosage lethal (SDL) and loss-of-function genetic interactions (GIs) for 92 kinases, producing a meta-network of 8700 GIs enriched for pathways known to be regulated ... [more]
Quantitative Score
- -0.25 [SGA Score]
Throughput
- High Throughput
Ontology Terms
- phenotype: vegetative growth (APO:0000106)
- phenotype: colony size (APO:0000063)
Additional Notes
- score threshold <= -0.12, interaction detected by Synthetic Genetic Array (SGA)
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| ELM1 UME6 | Negative Genetic Negative Genetic Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores. | High | -4.2451 | BioGRID | 541003 | |
| UME6 ELM1 | Negative Genetic Negative Genetic Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores. | High | -0.2504 | BioGRID | 368192 | |
| ELM1 UME6 | Negative Genetic Negative Genetic Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores. | High | -0.2504 | BioGRID | 394459 | |
| ELM1 UME6 | Negative Genetic Negative Genetic Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores. | High | -0.2216 | BioGRID | 2142393 | |
| UME6 ELM1 | Synthetic Lethality Synthetic Lethality A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition. | High | - | BioGRID | 3675431 |
Curated By
- BioGRID