BAIT

BCK1

LAS3, SAP3, SLK1, SSP31, mitogen-activated protein kinase kinase kinase BCK1, L000000162, YJL095W

MAPKKK acting in the protein kinase C signaling pathway; the kinase C signaling pathway controls cell integrity; upon activation by Pkc1p phosphorylates downstream kinases Mkk1p and Mkk2p; MAPKKK is an acronym for mitogen-activated protein (MAP) kinase kinase kinase

Kinome Project (Sc)

GO Process (8)

GO Function (2)

GO Component (2)

Gene Ontology Biological Process

endoplasmic reticulum unfolded protein response [IMP]

establishment of cell polarity [IMP]

intracellular signal transduction [IMP]

peroxisome degradation [IMP]

protein phosphorylation [IDA, TAS]

regulation of fungal-type cell wall organization [IGI, IMP]

response to acidic pH [IMP]

response to nutrient [IMP]

Gene Ontology Molecular Function

MAP kinase kinase kinase activity [IGI]
protein kinase activity [IDA]

Gene Ontology Cellular Component

cytoplasm [IDA]

mating projection tip [IDA]

SGD Alliance of Genome Resources Entrez Gene RefSeq UniprotKB

Saccharomyces cerevisiae (S288c)

PREY

ECM8

L000003883, YBR076W

Non-essential protein of unknown function

GO Process (0)

GO Function (0)

GO Component (0)

SGD Alliance of Genome Resources Entrez Gene RefSeq UniprotKB

Saccharomyces cerevisiae (S288c)

Negative Genetic

Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores.

Publication

Functional wiring of the yeast kinome revealed by global analysis of genetic network motifs.

Sharifpoor S, van Dyk D, Costanzo M, Baryshnikova A, Friesen H, Douglas AC, Youn JY, Vandersluis B, Myers CL, Papp B, Boone C, Andrews BJ

A combinatorial genetic perturbation strategy was applied to interrogate the yeast kinome on a genome-wide scale. We assessed the global effects of gene overexpression or gene deletion to map an integrated genetic interaction network of synthetic dosage lethal (SDL) and loss-of-function genetic interactions (GIs) for 92 kinases, producing a meta-network of 8700 GIs enriched for pathways known to be regulated ... [more]

Unknown Feb. 17, 2012; 0(0); [Pubmed: 22282571]

Quantitative Score

-0.186 [SGA Score]

Throughput

High Throughput

Ontology Terms

phenotype: vegetative growth (APO:0000106)
phenotype: colony size (APO:0000063)

Additional Notes

score threshold <= -0.12, interaction detected by Synthetic Genetic Array (SGA)

Related interactions

Interaction	Experimental Evidence Code	Dataset	Throughput	Score	Curated By	Notes
BCK1 ECM8	Negative Genetic Negative Genetic Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores.	Costanzo M (2010)	High	-0.1864	BioGRID	390588
ECM8 BCK1	Negative Genetic Negative Genetic Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores.	Costanzo M (2010)	High	-0.1864	BioGRID	357601
BCK1 ECM8	Negative Genetic Negative Genetic Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores.	Costanzo M (2016)	High	-0.2059	BioGRID	2135935

Curated By

BioGRID

Interaction Summary