BAIT

PAU12

seripauperin PAU12, YGR294W

Protein of unknown function; member of the seripauperin multigene family encoded mainly in subtelomeric regions

GO Process (0)

GO Function (0)

GO Component (0)

SGD Alliance of Genome Resources Entrez Gene RefSeq UniprotKB

Saccharomyces cerevisiae (S288c)

PREY

ELM1

LDB9, serine/threonine protein kinase ELM1, L000000548, YKL048C

Serine/threonine protein kinase that regulates cellular morphogenesis; septin behavior, and cytokinesis; required for the regulation of other kinases, such as Kin4p; forms part of the bud neck ring

Kinome Project (Sc)

GO Process (11)

GO Function (2)

GO Component (1)

Gene Ontology Biological Process

axial cellular bud site selection [TAS]

budding cell bud growth [IMP]

cell morphogenesis [IMP]

cytokinesis checkpoint [TAS]

glucose metabolic process [IGI, IMP]

positive regulation of protein autophosphorylation [IDA, IMP]

protein autophosphorylation [IDA, IMP]

protein phosphorylation [IDA, IGI]

pseudohyphal growth [IMP]

response to drug [IMP]

response to osmotic stress [TAS]

Gene Ontology Molecular Function

protein kinase activity [IDA]
protein serine/threonine kinase activity [IDA]

Gene Ontology Cellular Component

cellular bud neck contractile ring [TAS]

SGD Alliance of Genome Resources Entrez Gene RefSeq UniprotKB

Saccharomyces cerevisiae (S288c)

Negative Genetic

Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores.

Publication

Functional wiring of the yeast kinome revealed by global analysis of genetic network motifs.

Sharifpoor S, van Dyk D, Costanzo M, Baryshnikova A, Friesen H, Douglas AC, Youn JY, Vandersluis B, Myers CL, Papp B, Boone C, Andrews BJ

A combinatorial genetic perturbation strategy was applied to interrogate the yeast kinome on a genome-wide scale. We assessed the global effects of gene overexpression or gene deletion to map an integrated genetic interaction network of synthetic dosage lethal (SDL) and loss-of-function genetic interactions (GIs) for 92 kinases, producing a meta-network of 8700 GIs enriched for pathways known to be regulated ... [more]

Unknown Feb. 17, 2012; 0(0); [Pubmed: 22282571]

Quantitative Score

-0.139 [SGA Score]

Throughput

High Throughput

Ontology Terms

phenotype: vegetative growth (APO:0000106)
phenotype: colony size (APO:0000063)

Additional Notes

score threshold <= -0.12, interaction detected by Synthetic Genetic Array (SGA)

Related interactions

Interaction	Experimental Evidence Code	Dataset	Throughput	Score	Curated By	Notes
PAU12 ELM1	Negative Genetic Negative Genetic Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores.	Costanzo M (2010)	High	-0.1391	BioGRID	384692
PAU12 ELM1	Negative Genetic Negative Genetic Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores.	Costanzo M (2016)	High	-0.2031	BioGRID	2124410

Curated By

BioGRID

Interaction Summary