LATS2
Gene Ontology Biological Process
- G1/S transition of mitotic cell cycle [IDA]
- hippo signaling [IDA, TAS]
- hormone-mediated signaling pathway [IDA]
- intracellular signal transduction [IDA]
- negative regulation of canonical Wnt signaling pathway [IMP]
- negative regulation of cyclin-dependent protein serine/threonine kinase activity [IDA]
- protein phosphorylation [IDA]
Gene Ontology Molecular Function
LONP1
Gene Ontology Biological Process
- cellular response to oxidative stress [IC, IDA]
- mitochondrial DNA metabolic process [NAS]
- mitochondrial genome maintenance [NAS]
- mitochondrion organization [IMP]
- oxidation-dependent protein catabolic process [IMP]
- protein homooligomerization [IDA]
- proteolysis involved in cellular protein catabolic process [IDA]
- response to hypoxia [IEP]
Gene Ontology Molecular Function- ADP binding [IDA]
- ATP binding [IDA]
- ATP-dependent peptidase activity [IDA]
- DNA polymerase binding [IPI]
- G-quadruplex DNA binding [IDA]
- mitochondrial heavy strand promoter anti-sense binding [IDA]
- mitochondrial heavy strand promoter sense binding [IDA]
- mitochondrial light strand promoter anti-sense binding [IDA]
- mitochondrial light strand promoter sense binding [IDA]
- protein binding [IPI]
- sequence-specific DNA binding [IDA]
- single-stranded RNA binding [IDA]
- ADP binding [IDA]
- ATP binding [IDA]
- ATP-dependent peptidase activity [IDA]
- DNA polymerase binding [IPI]
- G-quadruplex DNA binding [IDA]
- mitochondrial heavy strand promoter anti-sense binding [IDA]
- mitochondrial heavy strand promoter sense binding [IDA]
- mitochondrial light strand promoter anti-sense binding [IDA]
- mitochondrial light strand promoter sense binding [IDA]
- protein binding [IPI]
- sequence-specific DNA binding [IDA]
- single-stranded RNA binding [IDA]
Gene Ontology Cellular Component
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Protein interaction network of the Mammalian hippo pathway reveals mechanisms of kinase-phosphatase interactions.
The Hippo pathway regulates organ size and tissue homeostasis in response to multiple stimuli, including cell density and mechanotransduction. Pharmacological inhibition of phosphatases can also stimulate Hippo signaling in cell culture. We defined the Hippo protein-protein interaction network with and without inhibition of serine and threonine phosphatases by okadaic acid. We identified 749 protein interactions, including 599 previously unrecognized interactions, ... [more]
Quantitative Score
- 0.89 [Saint Score]
Throughput
- High Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| LATS2 LONP1 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | 1462 | BioGRID | 3486853 |
Curated By
- BioGRID