YWHAB
Gene Ontology Biological Process
- Fc-epsilon receptor signaling pathway [TAS]
- MAPK cascade [TAS]
- RNA metabolic process [TAS]
- Ras protein signal transduction [TAS]
- activation of MAPKK activity [TAS]
- apoptotic process [TAS]
- axon guidance [TAS]
- cytoplasmic sequestering of protein [IDA]
- epidermal growth factor receptor signaling pathway [TAS]
- fibroblast growth factor receptor signaling pathway [TAS]
- gene expression [TAS]
- hippo signaling [TAS]
- innate immune response [TAS]
- insulin receptor signaling pathway [TAS]
- intrinsic apoptotic signaling pathway [TAS]
- mRNA metabolic process [TAS]
- membrane organization [TAS]
- negative regulation of protein dephosphorylation [IDA]
- neurotrophin TRK receptor signaling pathway [TAS]
- positive regulation of catalytic activity [IDA]
- positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway [TAS]
- small GTPase mediated signal transduction [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
DMTN
Gene Ontology Biological Process
- actin cytoskeleton organization [ISS]
- actin filament bundle assembly [IDA, TAS]
- actin filament reorganization [ISS]
- calcium-mediated signaling using extracellular calcium source [ISS]
- calcium-mediated signaling using intracellular calcium source [ISS]
- cellular response to cAMP [IDA]
- cellular response to calcium ion [ISS]
- cytoskeleton organization [TAS]
- erythrocyte development [ISS]
- negative regulation of cell-substrate adhesion [ISS]
- negative regulation of focal adhesion assembly [ISS]
- negative regulation of peptidyl-serine phosphorylation [ISS]
- negative regulation of peptidyl-threonine phosphorylation [ISS]
- negative regulation of peptidyl-tyrosine phosphorylation [ISS]
- negative regulation of protein targeting to membrane [ISS]
- negative regulation of substrate adhesion-dependent cell spreading [ISS]
- positive regulation of blood coagulation [ISS]
- positive regulation of fibroblast migration [ISS]
- positive regulation of integrin-mediated signaling pathway [ISS]
- positive regulation of platelet aggregation [ISS]
- positive regulation of substrate adhesion-dependent cell spreading [ISS]
- positive regulation of wound healing [ISS]
- protein complex assembly [IDA, ISS]
- protein secretion by platelet [ISS]
- regulation of actin cytoskeleton organization [IDA]
- regulation of cell shape [IMP]
- regulation of filopodium assembly [IMP]
- regulation of lamellipodium assembly [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Protein interaction network of the Mammalian hippo pathway reveals mechanisms of kinase-phosphatase interactions.
The Hippo pathway regulates organ size and tissue homeostasis in response to multiple stimuli, including cell density and mechanotransduction. Pharmacological inhibition of phosphatases can also stimulate Hippo signaling in cell culture. We defined the Hippo protein-protein interaction network with and without inhibition of serine and threonine phosphatases by okadaic acid. We identified 749 protein interactions, including 599 previously unrecognized interactions, ... [more]
Quantitative Score
- 0.99 [Saint Score]
Throughput
- High Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| DMTN YWHAB | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | 0.8132 | BioGRID | 2267463 | |
| YWHAB DMTN | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | 1 | BioGRID | 3083275 | |
| DMTN YWHAB | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | 0.9512 | BioGRID | 3169589 | |
| YWHAB DMTN | Proximity Label-MS Proximity Label-MS An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods. | High | - | BioGRID | 3536089 |
Curated By
- BioGRID