PRKACA
Gene Ontology Biological Process
- G2/M transition of mitotic cell cycle [TAS]
- activation of phospholipase C activity [TAS]
- activation of protein kinase A activity [TAS]
- blood coagulation [TAS]
- calcium-mediated signaling using intracellular calcium source [TAS]
- carbohydrate metabolic process [TAS]
- cell communication by electrical coupling involved in cardiac conduction [TAS]
- cellular response to epinephrine stimulus [TAS]
- cellular response to glucagon stimulus [TAS]
- cellular response to glucose stimulus [IDA]
- cytosolic calcium ion homeostasis [TAS]
- energy reserve metabolic process [TAS]
- epidermal growth factor receptor signaling pathway [TAS]
- fibroblast growth factor receptor signaling pathway [TAS]
- gluconeogenesis [TAS]
- glucose metabolic process [TAS]
- innate immune response [TAS]
- intracellular signal transduction [TAS]
- mitotic cell cycle [TAS]
- neurotrophin TRK receptor signaling pathway [TAS]
- peptidyl-serine phosphorylation [IDA]
- positive regulation of cell cycle arrest [ISS]
- protein phosphorylation [NAS]
- regulation of cardiac muscle contraction [TAS]
- regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion [TAS]
- regulation of heart rate [TAS]
- regulation of insulin secretion [TAS]
- regulation of osteoblast differentiation [IDA]
- regulation of proteasomal protein catabolic process [IDA]
- regulation of protein binding [TAS]
- regulation of ryanodine-sensitive calcium-release channel activity [TAS]
- regulation of tight junction assembly [IDA]
- signal transduction [TAS]
- small molecule metabolic process [TAS]
- sperm capacitation [ISS]
- transmembrane transport [TAS]
- triglyceride catabolic process [TAS]
- water transport [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
CYP3A4
Gene Ontology Biological Process
- alkaloid catabolic process [IDA]
- androgen metabolic process [TAS]
- calcitriol biosynthetic process from calciol [IDA]
- drug catabolic process [IDA, IMP]
- drug metabolic process [IDA]
- exogenous drug catabolic process [IDA]
- heterocycle metabolic process [IDA]
- lipid metabolic process [TAS]
- monoterpenoid metabolic process [IDA]
- oxidation-reduction process [IDA]
- oxidative demethylation [IDA]
- small molecule metabolic process [TAS]
- steroid catabolic process [IMP]
- steroid metabolic process [IMP]
- vitamin D metabolic process [IC]
- xenobiotic metabolic process [TAS]
Gene Ontology Molecular Function- caffeine oxidase activity [IDA]
- enzyme binding [IPI]
- iron ion binding [IDA]
- monooxygenase activity [IDA, ISS]
- oxidoreductase activity [IDA]
- oxygen binding [TAS]
- steroid binding [IDA]
- steroid hydroxylase activity [IMP]
- testosterone 6-beta-hydroxylase activity [IMP]
- vitamin D 24-hydroxylase activity [IDA]
- vitamin D3 25-hydroxylase activity [IDA]
- caffeine oxidase activity [IDA]
- enzyme binding [IPI]
- iron ion binding [IDA]
- monooxygenase activity [IDA, ISS]
- oxidoreductase activity [IDA]
- oxygen binding [TAS]
- steroid binding [IDA]
- steroid hydroxylase activity [IMP]
- testosterone 6-beta-hydroxylase activity [IMP]
- vitamin D 24-hydroxylase activity [IDA]
- vitamin D3 25-hydroxylase activity [IDA]
Gene Ontology Cellular Component
Biochemical Activity (Phosphorylation)
An interaction is inferred from the biochemical effect of one protein upon another, for example, GTP-GDP exchange activity or phosphorylation of a substrate by a kinase. The bait protein executes the activity on the substrate hit protein. A Modification value is recorded for interactions of this type with the possible values Phosphorylation, Ubiquitination, Sumoylation, Dephosphorylation, Methylation, Prenylation, Acetylation, Deubiquitination, Proteolytic Processing, Glucosylation, Nedd(Rub1)ylation, Deacetylation, No Modification, Demethylation.
Publication
Multisite phosphorylation of human liver cytochrome P450 3A4 enhances its gp78- and CHIP-mediated ubiquitination: A pivotal role of its S478 residue in the gp78-catalyzed reaction.
CYP3A4, an integral endoplasmic reticulum (ER)-anchored protein, is the major human liver cytochrome P450 enzyme responsible for the disposition of over 50% of clinically relevant drugs. Alterations of its protein turnover can influence drug metabolism, drug-drug interactions and the bioavailability of chemotherapeutic drugs. Such CYP3A4 turnover occurs via a classical ER-associated degradation (ERAD) process involving ubiquitination by both UBC7/gp78 and ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID