PRKCA
Gene Ontology Biological Process
- RNA metabolic process [TAS]
- activation of adenylate cyclase activity [ISS]
- activation of phospholipase C activity [TAS]
- apoptotic signaling pathway [TAS]
- blood coagulation [TAS]
- desmosome assembly [IMP]
- energy reserve metabolic process [TAS]
- epidermal growth factor receptor signaling pathway [TAS]
- extracellular matrix organization [TAS]
- fibroblast growth factor receptor signaling pathway [TAS]
- gene expression [TAS]
- histone H3-T6 phosphorylation [IDA]
- innate immune response [TAS]
- mRNA metabolic process [TAS]
- negative regulation of adenylate cyclase activity [ISS]
- negative regulation of glial cell apoptotic process [IMP]
- neurotrophin TRK receptor signaling pathway [TAS]
- phototransduction, visible light [TAS]
- platelet activation [TAS]
- positive regulation of ERK1 and ERK2 cascade [ISS]
- positive regulation of angiogenesis [IMP]
- positive regulation of blood vessel endothelial cell migration [IDA]
- positive regulation of cardiac muscle hypertrophy [ISS]
- positive regulation of cell adhesion [IMP]
- positive regulation of cell migration [IMP]
- positive regulation of dense core granule biogenesis [ISS]
- positive regulation of endothelial cell migration [IMP]
- positive regulation of endothelial cell proliferation [IMP]
- positive regulation of lipopolysaccharide-mediated signaling pathway [IMP]
- positive regulation of macrophage differentiation [ISS]
- positive regulation of mitotic cell cycle [IMP]
- protein phosphorylation [IDA]
- regulation of insulin secretion [TAS]
- regulation of platelet aggregation [IDA]
- regulation of rhodopsin mediated signaling pathway [TAS]
- response to interleukin-1 [IMP]
- rhodopsin mediated signaling pathway [TAS]
- signal transduction [TAS]
- small molecule metabolic process [TAS]
- synaptic transmission [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
CYP3A4
Gene Ontology Biological Process
- alkaloid catabolic process [IDA]
- androgen metabolic process [TAS]
- calcitriol biosynthetic process from calciol [IDA]
- drug catabolic process [IDA, IMP]
- drug metabolic process [IDA]
- exogenous drug catabolic process [IDA]
- heterocycle metabolic process [IDA]
- lipid metabolic process [TAS]
- monoterpenoid metabolic process [IDA]
- oxidation-reduction process [IDA]
- oxidative demethylation [IDA]
- small molecule metabolic process [TAS]
- steroid catabolic process [IMP]
- steroid metabolic process [IMP]
- vitamin D metabolic process [IC]
- xenobiotic metabolic process [TAS]
Gene Ontology Molecular Function- caffeine oxidase activity [IDA]
- enzyme binding [IPI]
- iron ion binding [IDA]
- monooxygenase activity [IDA, ISS]
- oxidoreductase activity [IDA]
- oxygen binding [TAS]
- steroid binding [IDA]
- steroid hydroxylase activity [IMP]
- testosterone 6-beta-hydroxylase activity [IMP]
- vitamin D 24-hydroxylase activity [IDA]
- vitamin D3 25-hydroxylase activity [IDA]
- caffeine oxidase activity [IDA]
- enzyme binding [IPI]
- iron ion binding [IDA]
- monooxygenase activity [IDA, ISS]
- oxidoreductase activity [IDA]
- oxygen binding [TAS]
- steroid binding [IDA]
- steroid hydroxylase activity [IMP]
- testosterone 6-beta-hydroxylase activity [IMP]
- vitamin D 24-hydroxylase activity [IDA]
- vitamin D3 25-hydroxylase activity [IDA]
Gene Ontology Cellular Component
Biochemical Activity (Phosphorylation)
An interaction is inferred from the biochemical effect of one protein upon another, for example, GTP-GDP exchange activity or phosphorylation of a substrate by a kinase. The bait protein executes the activity on the substrate hit protein. A Modification value is recorded for interactions of this type with the possible values Phosphorylation, Ubiquitination, Sumoylation, Dephosphorylation, Methylation, Prenylation, Acetylation, Deubiquitination, Proteolytic Processing, Glucosylation, Nedd(Rub1)ylation, Deacetylation, No Modification, Demethylation.
Publication
Multisite phosphorylation of human liver cytochrome P450 3A4 enhances its gp78- and CHIP-mediated ubiquitination: A pivotal role of its S478 residue in the gp78-catalyzed reaction.
CYP3A4, an integral endoplasmic reticulum (ER)-anchored protein, is the major human liver cytochrome P450 enzyme responsible for the disposition of over 50% of clinically relevant drugs. Alterations of its protein turnover can influence drug metabolism, drug-drug interactions and the bioavailability of chemotherapeutic drugs. Such CYP3A4 turnover occurs via a classical ER-associated degradation (ERAD) process involving ubiquitination by both UBC7/gp78 and ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID