BAIT
HECW2
NEDL2
HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2
GO Process (1)
GO Function (1)
GO Component (2)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Homo sapiens
PREY
LAMC1
LAMB2, RP11-181K3.1
laminin, gamma 1 (formerly LAMB2)
GO Process (10)
GO Function (1)
GO Component (8)
Gene Ontology Biological Process
- axon guidance [TAS]
- cell adhesion [IDA]
- cell migration [IMP]
- endoderm development [TAS]
- extracellular matrix disassembly [IMP, TAS]
- extracellular matrix organization [TAS]
- hemidesmosome assembly [IMP]
- positive regulation of epithelial cell proliferation [TAS]
- protein complex assembly [IDA]
- substrate adhesion-dependent cell spreading [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
HECT Type Ubiquitin Ligase NEDL2 is Degraded by APC/C-Cdh1 and its Tight Regulation Maintains the Metaphase to Anaphase Transition.
NEDD4-like ubiquitin ligase 2 (NEDL2) is a HECT type ubiquitin ligase. NEDL2 enhances p73 transcriptional activity and degrades ATR kinase in lamin misexpressed cells. Compared to the important functions of other HECT type ubiquitin ligase, there is less study concerning the function and regulation of NEDL2. Using primary antibody immunoprecipitation and mass spectrometry (IP/MS), we identify a list of potential ... [more]
J. Biol. Chem. Oct. 25, 2013; 0(0); [Pubmed: 24163370]
Throughput
- High Throughput
Curated By
- BioGRID