TIRAP
Gene Ontology Biological Process
- 3'-UTR-mediated mRNA stabilization [IDA]
- MyD88-dependent toll-like receptor signaling pathway [TAS]
- TIRAP-dependent toll-like receptor 4 signaling pathway [IDA]
- cell surface receptor signaling pathway [ISS]
- cellular response to bacterial lipopeptide [ISS]
- cellular response to lipoteichoic acid [ISS]
- defense response to Gram-positive bacterium [ISS]
- innate immune response [TAS]
- myeloid cell differentiation [ISS]
- negative regulation of growth of symbiont in host [ISS]
- positive regulation of B cell proliferation [ISS]
- positive regulation of ERK1 and ERK2 cascade [IMP]
- positive regulation of I-kappaB kinase/NF-kappaB signaling [IMP]
- positive regulation of JNK cascade [IMP]
- positive regulation of NF-kappaB transcription factor activity [IMP]
- positive regulation of chemokine (C-X-C motif) ligand 1 production [ISS]
- positive regulation of chemokine (C-X-C motif) ligand 2 production [ISS]
- positive regulation of interleukin-12 production [ISS]
- positive regulation of interleukin-15 production [IDA]
- positive regulation of interleukin-6 biosynthetic process [IMP]
- positive regulation of interleukin-8 production [IMP]
- positive regulation of neutrophil chemotaxis [ISS]
- positive regulation of protein homodimerization activity [IDA]
- positive regulation of toll-like receptor 2 signaling pathway [IMP]
- positive regulation of toll-like receptor 3 signaling pathway [ISS]
- positive regulation of toll-like receptor 4 signaling pathway [IMP]
- positive regulation of tumor necrosis factor production [IMP]
- regulation of innate immune response [IC]
- regulation of interferon-beta production [ISS]
- response to lipopolysaccharide [IDA]
- toll-like receptor 2 signaling pathway [TAS]
- toll-like receptor 4 signaling pathway [TAS]
- toll-like receptor TLR1:TLR2 signaling pathway [TAS]
- toll-like receptor TLR6:TLR2 signaling pathway [TAS]
- toll-like receptor signaling pathway [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
MAP3K7
Gene Ontology Biological Process
- Fc-epsilon receptor signaling pathway [TAS]
- I-kappaB kinase/NF-kappaB signaling [TAS]
- I-kappaB phosphorylation [IDA]
- JNK cascade [IDA, TAS]
- MyD88-dependent toll-like receptor signaling pathway [TAS]
- MyD88-independent toll-like receptor signaling pathway [TAS]
- T cell receptor signaling pathway [NAS, TAS]
- TRIF-dependent toll-like receptor signaling pathway [TAS]
- activation of MAPK activity [IDA, TAS]
- activation of MAPKK activity [IDA]
- activation of NF-kappaB-inducing kinase activity [IMP]
- histone H3 acetylation [IDA]
- innate immune response [TAS]
- nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway [TAS]
- nucleotide-binding oligomerization domain containing signaling pathway [TAS]
- positive regulation of I-kappaB kinase/NF-kappaB signaling [IMP]
- positive regulation of JUN kinase activity [IDA, IMP]
- positive regulation of NF-kappaB transcription factor activity [TAS]
- positive regulation of T cell activation [IC]
- positive regulation of T cell cytokine production [IMP]
- positive regulation of interleukin-2 production [IMP]
- stress-activated MAPK cascade [IDA, TAS]
- toll-like receptor 10 signaling pathway [TAS]
- toll-like receptor 2 signaling pathway [TAS]
- toll-like receptor 3 signaling pathway [TAS]
- toll-like receptor 4 signaling pathway [TAS]
- toll-like receptor 5 signaling pathway [TAS]
- toll-like receptor 9 signaling pathway [TAS]
- toll-like receptor TLR1:TLR2 signaling pathway [TAS]
- toll-like receptor TLR6:TLR2 signaling pathway [TAS]
- toll-like receptor signaling pathway [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
The TNF family member 4-1BBL sustains inflammation by interacting with TLR signaling components during late-phase activation.
Activation of Toll-like receptor (TLR)-dependent signaling leads to the expression of genes encoding proinflammatory factors, such as tumor necrosis factor-α (TNF-α), and this proinflammatory gene expression is sustained for the duration of the inflammatory response. TLR4-mediated inflammation, which occurs in two phases, depends on the TNF family member 4-1BB ligand (4-1BBL) to sustain TNF-α production during late-phase signaling. We showed ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| TIRAP MAP3K7 | Phenotypic Suppression Phenotypic Suppression A genetic interaction is inferred when mutation or over expression of one gene results in suppression of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene. | Low | - | BioGRID | - |
Curated By
- BioGRID