BAIT
STK11
AA408040, Lkb1, Par-4, R75140
serine/threonine kinase 11
GO Process (33)
GO Function (8)
GO Component (8)
Gene Ontology Biological Process
- Golgi localization [IMP]
- T cell receptor signaling pathway [IGI, IMP]
- TCR signalosome assembly [IMP]
- activation of protein kinase activity [IDA, ISO]
- anoikis [ISO]
- axonogenesis [IMP, ISO]
- canonical Wnt signaling pathway [IMP]
- cell cycle arrest [ISO]
- dendrite extension [IMP]
- establishment of cell polarity [IMP]
- glucose homeostasis [IMP]
- intrinsic apoptotic signaling pathway by p53 class mediator [ISO]
- negative regulation of cell growth [IDA]
- negative regulation of cell proliferation [ISO]
- negative regulation of epithelial cell proliferation involved in prostate gland development [IMP]
- positive regulation of axonogenesis [IGI]
- positive regulation of gluconeogenesis [ISO]
- positive regulation of peptidyl-tyrosine phosphorylation [IMP]
- positive regulation of protein kinase activity [IMP]
- positive regulation of transforming growth factor beta receptor signaling pathway [IMP, ISO]
- positive thymic T cell selection [IMP]
- protein autophosphorylation [IDA, ISO]
- protein heterooligomerization [ISO]
- protein phosphorylation [IMP, ISO]
- regulation of Wnt signaling pathway [IMP]
- regulation of cell growth [IDA]
- regulation of dendrite morphogenesis [IMP]
- regulation of protein kinase B signaling [IMP]
- response to ionizing radiation [IDA]
- response to lipid [ISO]
- spermatid development [IMP]
- tissue homeostasis [IMP]
- vasculature development [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
EIF4B
EIF-4B, PRO1843
eukaryotic translation initiation factor 4B
GO Process (10)
GO Function (3)
GO Component (2)
Gene Ontology Biological Process
- RNA metabolic process [TAS]
- cellular protein metabolic process [TAS]
- gene expression [TAS]
- insulin receptor signaling pathway [TAS]
- mRNA metabolic process [TAS]
- nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay [TAS]
- nuclear-transcribed mRNA poly(A) tail shortening [TAS]
- regulation of translational initiation [TAS]
- translation [TAS]
- translational initiation [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Heat-shock protein 90 and Cdc37 interact with LKB1 and regulate its stability.
LKB1 is a widely expressed serine/threonine protein kinase that is mutated in the inherited Peutz-Jeghers cancer syndrome. Recent findings indicate that LKB1 functions as a tumour suppressor, but little is known regarding the detailed mechanism by which LKB1 regulates cell growth. In this study we have purified LKB1 from cells and establish that it is associated with the heat-shock protein ... [more]
Biochem. J. Mar. 15, 2003; 370(0);849-57 [Pubmed: 12489981]
Throughput
- Low Throughput
Ontology Terms
- cell line: hela cell (BTO:0000567) [cervical adenocarcinoma (DOID:3702)]
Additional Notes
- exogenous expression of bait
Curated By
- BioGRID