BAIT
USP8
HumORF8, SPG59, UBPY
ubiquitin specific peptidase 8
GO Process (8)
GO Function (4)
GO Component (8)
Gene Ontology Biological Process
- cell proliferation [TAS]
- endosome organization [IMP]
- mitotic cytokinesis [IMP]
- proteasome-mediated ubiquitin-dependent protein catabolic process [IBA]
- protein K48-linked deubiquitination [IDA]
- protein K63-linked deubiquitination [IDA]
- protein deubiquitination [IMP]
- regulation of proteasomal protein catabolic process [IBA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
HTT
HD, IT15
huntingtin
GO Process (8)
GO Function (8)
GO Component (12)
Gene Ontology Biological Process
- Golgi organization [IMP]
- establishment of mitotic spindle orientation [IMP]
- negative regulation of extrinsic apoptotic signaling pathway [IMP]
- organ development [IBA]
- positive regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity [IDA]
- regulation of protein phosphatase type 2A activity [IMP]
- retrograde vesicle-mediated transport, Golgi to ER [IMP]
- vesicle transport along microtubule [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Co-fractionation
Interaction inferred from the presence of two or more protein subunits in a partially purified protein preparation. If co-fractionation is demonstrated between 3 or more proteins, then add them as a complex.
Publication
A high-throughput approach for measuring temporal changes in the interactome.
Interactomes are often measured using affinity purification-mass spectrometry (AP-MS) or yeast two-hybrid approaches, but these methods do not provide stoichiometric or temporal information. We combine quantitative proteomics and size-exclusion chromatography to map 291 coeluting complexes. This method allows mapping of an interactome to the same depth and accuracy as AP-MS with less work and without overexpression or tagging. The use ... [more]
Nat. Methods Sep. 01, 2012; 9(9);907-9 [Pubmed: 22863883]
Throughput
- High Throughput
Ontology Terms
- cell line: hela cell (BTO:0000567) [cervical adenocarcinoma (DOID:3702)]
Curated By
- BioGRID