BAIT
RIC8A
RIC8
RIC8 guanine nucleotide exchange factor A
GO Process (2)
GO Function (4)
GO Component (2)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Homo sapiens
PREY
MC1R
CMM5, MSH-R, SHEP2
melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor)
GO Process (12)
GO Function (5)
GO Component (2)
Gene Ontology Biological Process
- G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger [TAS]
- UV protection [TAS]
- UV-damage excision repair [IDA]
- intracellular signal transduction [ISS]
- multicellular organismal development [TAS]
- negative regulation of tumor necrosis factor production [IMP]
- pigmentation [TAS]
- positive regulation of cAMP biosynthetic process [IDA]
- positive regulation of protein kinase A signaling [ISS]
- positive regulation of protein kinase B signaling [ISS]
- positive regulation of protein kinase C signaling [ISS]
- positive regulation of transcription from RNA polymerase II promoter [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Co-fractionation
Interaction inferred from the presence of two or more protein subunits in a partially purified protein preparation. If co-fractionation is demonstrated between 3 or more proteins, then add them as a complex.
Publication
A high-throughput approach for measuring temporal changes in the interactome.
Interactomes are often measured using affinity purification-mass spectrometry (AP-MS) or yeast two-hybrid approaches, but these methods do not provide stoichiometric or temporal information. We combine quantitative proteomics and size-exclusion chromatography to map 291 coeluting complexes. This method allows mapping of an interactome to the same depth and accuracy as AP-MS with less work and without overexpression or tagging. The use ... [more]
Nat. Methods Sep. 01, 2012; 9(9);907-9 [Pubmed: 22863883]
Throughput
- High Throughput
Ontology Terms
- cell line: hela cell (BTO:0000567) [cervical adenocarcinoma (DOID:3702)]
Curated By
- BioGRID