BAIT
GCLC
GCL, GCS, GLCL, GLCLC
glutamate-cysteine ligase, catalytic subunit
GO Process (15)
GO Function (5)
GO Component (2)
Gene Ontology Biological Process
- cell redox homeostasis [IDA]
- cellular nitrogen compound metabolic process [TAS]
- cysteine metabolic process [IDA]
- glutamate metabolic process [IDA]
- glutathione biosynthetic process [IDA, IMP, TAS]
- glutathione derivative biosynthetic process [TAS]
- negative regulation of apoptotic process [IDA]
- negative regulation of transcription, DNA-templated [IDA]
- regulation of blood vessel size [IMP]
- response to heat [IDA]
- response to hormone [IDA]
- response to oxidative stress [IDA]
- small molecule metabolic process [TAS]
- sulfur amino acid metabolic process [TAS]
- xenobiotic metabolic process [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
PPID
CYP-40, CYPD
peptidylprolyl isomerase D
GO Process (10)
GO Function (8)
GO Component (3)
Gene Ontology Biological Process
- cellular response to UV-A [IMP]
- chaperone-mediated protein folding [IDA]
- lipid particle organization [IMP]
- negative regulation of transcription from RNA polymerase II promoter [IMP]
- positive regulation of apoptotic process [IMP]
- positive regulation of protein secretion [IMP]
- positive regulation of viral genome replication [IMP]
- protein complex assembly [IDA]
- protein folding [ISS]
- viral release from host cell [TAS]
Gene Ontology Molecular Function
Homo sapiens
Co-fractionation
Interaction inferred from the presence of two or more protein subunits in a partially purified protein preparation. If co-fractionation is demonstrated between 3 or more proteins, then add them as a complex.
Publication
A high-throughput approach for measuring temporal changes in the interactome.
Interactomes are often measured using affinity purification-mass spectrometry (AP-MS) or yeast two-hybrid approaches, but these methods do not provide stoichiometric or temporal information. We combine quantitative proteomics and size-exclusion chromatography to map 291 coeluting complexes. This method allows mapping of an interactome to the same depth and accuracy as AP-MS with less work and without overexpression or tagging. The use ... [more]
Nat. Methods Sep. 01, 2012; 9(9);907-9 [Pubmed: 22863883]
Throughput
- High Throughput
Ontology Terms
- cell line: hela cell (BTO:0000567) [cervical adenocarcinoma (DOID:3702)]
Curated By
- BioGRID