BAIT
SP100
lysp100b
SP100 nuclear antigen
GO Process (25)
GO Function (10)
GO Component (7)
Gene Ontology Biological Process
- DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator [IDA]
- chromatin remodeling [IBA]
- cytokine-mediated signaling pathway [TAS]
- interferon-gamma-mediated signaling pathway [IC, TAS]
- negative regulation of DNA binding [IDA]
- negative regulation of cellular component movement [IMP]
- negative regulation of endothelial cell migration [IMP]
- negative regulation of nucleic acid-templated transcription [IDA]
- negative regulation of protein export from nucleus [IMP]
- negative regulation of sequence-specific DNA binding transcription factor activity [IDA]
- negative regulation of transcription from RNA polymerase II promoter [IDA]
- negative regulation of transcription, DNA-templated [IDA, IMP]
- negative regulation of viral transcription [IDA]
- positive regulation of sequence-specific DNA binding transcription factor activity [IDA]
- positive regulation of transcription, DNA-templated [IDA, IMP]
- regulation of Fas signaling pathway [IMP]
- regulation of angiogenesis [IMP]
- regulation of extrinsic apoptotic signaling pathway via death domain receptors [IMP]
- response to cytokine [IDA]
- response to interferon-gamma [IDA, IMP]
- response to retinoic acid [IDA]
- response to type I interferon [IDA, IMP]
- retinoic acid receptor signaling pathway [IC]
- telomere maintenance [IMP]
- type I interferon signaling pathway [IC]
Gene Ontology Molecular Function- chromatin binding [IBA]
- chromo shadow domain binding [IPI]
- identical protein binding [IPI]
- kinase binding [IPI]
- protein binding [IPI]
- protein domain specific binding [IPI]
- protein homodimerization activity [IPI]
- transcription coactivator activity [IDA]
- transcription corepressor activity [IDA]
- transcription factor binding [IPI]
- chromatin binding [IBA]
- chromo shadow domain binding [IPI]
- identical protein binding [IPI]
- kinase binding [IPI]
- protein binding [IPI]
- protein domain specific binding [IPI]
- protein homodimerization activity [IPI]
- transcription coactivator activity [IDA]
- transcription corepressor activity [IDA]
- transcription factor binding [IPI]
Gene Ontology Cellular Component
Homo sapiens
PREY
SERPINE2
GDN, GDNPF, PI-7, PI7, PN-1, PN1, PNI
serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
GO Process (8)
GO Function (5)
GO Component (8)
Gene Ontology Biological Process
- negative regulation of blood coagulation [IC, IDA]
- negative regulation of endopeptidase activity [IBA]
- negative regulation of plasminogen activation [IMP]
- negative regulation of platelet aggregation [ISS]
- negative regulation of protein processing [IC]
- negative regulation of proteolysis [IDA]
- positive regulation of astrocyte differentiation [IDA]
- regulation of cell migration [NAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Co-fractionation
Interaction inferred from the presence of two or more protein subunits in a partially purified protein preparation. If co-fractionation is demonstrated between 3 or more proteins, then add them as a complex.
Publication
A high-throughput approach for measuring temporal changes in the interactome.
Interactomes are often measured using affinity purification-mass spectrometry (AP-MS) or yeast two-hybrid approaches, but these methods do not provide stoichiometric or temporal information. We combine quantitative proteomics and size-exclusion chromatography to map 291 coeluting complexes. This method allows mapping of an interactome to the same depth and accuracy as AP-MS with less work and without overexpression or tagging. The use ... [more]
Nat. Methods Sep. 01, 2012; 9(9);907-9 [Pubmed: 22863883]
Throughput
- High Throughput
Ontology Terms
- cell line: hela cell (BTO:0000567) [cervical adenocarcinoma (DOID:3702)]
Curated By
- BioGRID