BAIT
ILF3
CBTF, DRBF, DRBP76, MMP4, MPHOSPH4, MPP4, NF-AT-90, NF110, NF110b, NF90, NF90a, NF90b, NFAR, NFAR-1, NFAR2, TCP110, TCP80
interleukin enhancer binding factor 3, 90kDa
GO Process (5)
GO Function (5)
GO Component (7)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
VEGFA
MVCD1, VEGF, VPF, RP1-261G23.1
vascular endothelial growth factor A
GO Process (97)
GO Function (16)
GO Component (7)
Gene Ontology Biological Process
- VEGF-activated neuropilin signaling pathway [ISS]
- activation of protein kinase activity [IDA]
- angiogenesis [IDA]
- artery morphogenesis [ISS]
- basophil chemotaxis [IDA]
- blood coagulation [TAS]
- branching morphogenesis of an epithelial tube [ISS]
- camera-type eye morphogenesis [ISS]
- cardiac muscle fiber development [ISS]
- cardiac vascular smooth muscle cell development [ISS]
- cell maturation [ISS]
- cell migration involved in sprouting angiogenesis [IDA]
- cellular response to hypoxia [IDA, TAS]
- cellular response to vascular endothelial growth factor stimulus [IDA]
- commissural neuron axon guidance [ISS]
- coronary artery morphogenesis [ISS]
- coronary vein morphogenesis [ISS]
- dopaminergic neuron differentiation [ISS]
- endothelial cell chemotaxis [IDA]
- epithelial cell differentiation [ISS]
- eye photoreceptor cell development [ISS]
- growth [ISS]
- heart morphogenesis [ISS]
- in utero embryonic development [ISS]
- induction of positive chemotaxis [IDA, NAS]
- kidney development [ISS]
- lactation [ISS]
- lung development [ISS]
- lymph vessel morphogenesis [ISS]
- macrophage differentiation [IDA]
- mammary gland alveolus development [ISS]
- mesoderm development [ISS]
- monocyte differentiation [IDA]
- negative regulation of apoptotic process [IMP]
- negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [IDA]
- negative regulation of transcription from RNA polymerase II promoter [IDA]
- nervous system development [TAS]
- outflow tract morphogenesis [ISS]
- ovarian follicle development [ISS]
- patterning of blood vessels [ISS]
- platelet activation [TAS]
- platelet degranulation [TAS]
- positive chemotaxis [IDA]
- positive regulation of CREB transcription factor activity [IDA]
- positive regulation of ERK1 and ERK2 cascade [IDA]
- positive regulation of MAP kinase activity [IDA]
- positive regulation of angiogenesis [IDA, IMP]
- positive regulation of axon extension involved in axon guidance [ISS]
- positive regulation of blood vessel endothelial cell migration [IDA]
- positive regulation of branching involved in ureteric bud morphogenesis [ISS]
- positive regulation of cell adhesion [IDA]
- positive regulation of cell migration [IDA]
- positive regulation of cell migration involved in sprouting angiogenesis [IDA]
- positive regulation of cell proliferation [IDA]
- positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway [IDA]
- positive regulation of cellular component movement [IDA]
- positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway [IDA]
- positive regulation of endothelial cell migration [IDA]
- positive regulation of endothelial cell proliferation [IDA, ISS]
- positive regulation of epithelial cell proliferation [ISS]
- positive regulation of focal adhesion assembly [IDA]
- positive regulation of gene expression [IDA]
- positive regulation of histone deacetylase activity [IDA]
- positive regulation of leukocyte migration [TAS]
- positive regulation of mast cell chemotaxis [IDA]
- positive regulation of mesenchymal cell proliferation [ISS]
- positive regulation of neuroblast proliferation [ISS]
- positive regulation of p38MAPK cascade [IDA]
- positive regulation of peptidyl-serine phosphorylation [IDA]
- positive regulation of peptidyl-tyrosine autophosphorylation [IDA]
- positive regulation of peptidyl-tyrosine phosphorylation [IDA]
- positive regulation of positive chemotaxis [IDA]
- positive regulation of protein autophosphorylation [IDA]
- positive regulation of protein complex assembly [IDA]
- positive regulation of protein kinase C signaling [IDA]
- positive regulation of protein kinase D signaling [IDA]
- positive regulation of protein localization to early endosome [IDA]
- positive regulation of protein phosphorylation [IDA]
- positive regulation of receptor internalization [IDA]
- positive regulation of retinal ganglion cell axon guidance [ISS]
- positive regulation of transcription from RNA polymerase II promoter [IDA, IMP]
- positive regulation of transcription from RNA polymerase II promoter in response to hypoxia [IMP]
- positive regulation of vascular endothelial growth factor receptor signaling pathway [IDA]
- positive regulation of vascular permeability [IDA]
- post-embryonic camera-type eye development [ISS]
- primitive erythrocyte differentiation [ISS]
- regulation of cGMP metabolic process [IDA]
- regulation of cell shape [IDA]
- regulation of retinal ganglion cell axon guidance [ISS]
- regulation of transcription from RNA polymerase II promoter [IMP]
- regulation of transcription from RNA polymerase II promoter in response to hypoxia [TAS]
- response to hypoxia [IDA]
- surfactant homeostasis [ISS]
- tube formation [IDA]
- vascular endothelial growth factor receptor signaling pathway [IDA, TAS]
- vascular endothelial growth factor signaling pathway [IDA]
- vasculogenesis [TAS]
Gene Ontology Molecular Function- chemoattractant activity [IDA]
- cytokine activity [IDA, ISS]
- extracellular matrix binding [IC]
- fibronectin binding [IDA]
- growth factor activity [IDA, ISS]
- heparin binding [IDA, IMP]
- identical protein binding [IPI]
- neuropilin binding [IPI]
- platelet-derived growth factor receptor binding [IPI]
- protein binding [IPI]
- protein heterodimerization activity [IDA]
- protein homodimerization activity [ISS]
- receptor agonist activity [IPI]
- vascular endothelial growth factor receptor 1 binding [IPI]
- vascular endothelial growth factor receptor 2 binding [IPI]
- vascular endothelial growth factor receptor binding [IPI]
- chemoattractant activity [IDA]
- cytokine activity [IDA, ISS]
- extracellular matrix binding [IC]
- fibronectin binding [IDA]
- growth factor activity [IDA, ISS]
- heparin binding [IDA, IMP]
- identical protein binding [IPI]
- neuropilin binding [IPI]
- platelet-derived growth factor receptor binding [IPI]
- protein binding [IPI]
- protein heterodimerization activity [IDA]
- protein homodimerization activity [ISS]
- receptor agonist activity [IPI]
- vascular endothelial growth factor receptor 1 binding [IPI]
- vascular endothelial growth factor receptor 2 binding [IPI]
- vascular endothelial growth factor receptor binding [IPI]
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-RNA
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and associated RNA species identified by Northern blot, RT-PCR, affinity labeling, sequencing, or microarray analysis.
Publication
The HILDA complex coordinates a conditional switch in the 3'-untranslated region of the VEGFA mRNA.
Cell regulatory circuits integrate diverse, and sometimes conflicting, environmental cues to generate appropriate, condition-dependent responses. Here, we elucidate the components and mechanisms driving a protein-directed RNA switch in the 3'UTR of vascular endothelial growth factor (VEGF)-A. We describe a novel HILDA (hypoxia-inducible hnRNP L-DRBP76-hnRNP A2/B1) complex that coordinates a three-element RNA switch, enabling VEGFA mRNA translation during combined hypoxia and ... [more]
PLoS Biol. Aug. 27, 2013; 11(8);e1001635 [Pubmed: 23976881]
Throughput
- Low Throughput
Additional Notes
- in the presence of ILF3 and HNRNPA2B1
Curated By
- BioGRID