PRPF19
Gene Ontology Biological Process
- cellular protein localization [IMP]
- double-strand break repair via nonhomologous end joining [IMP]
- generation of catalytic spliceosome for first transesterification step [IBA]
- mRNA splicing, via spliceosome [IC, IDA]
- proteasomal protein catabolic process [IMP]
- protein K63-linked ubiquitination [IMP]
- protein polyubiquitination [IDA]
- signal transduction involved in DNA damage checkpoint [IMP]
- spliceosomal complex assembly [IMP]
- spliceosomal tri-snRNP complex assembly [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
EXOC3
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Co-localization
Interaction inferred from two proteins that co-localize in the cell by indirect immunofluorescence only when in addition, if one gene is deleted, the other protein becomes mis-localized. Also includes co-dependent association of proteins with promoter DNA in chromatin immunoprecipitation experiments.
Publication
Exo70, a subunit of the exocyst complex, interacts with SNEV(hPrp19/hPso4) and is involved in pre-mRNA splicing.
The Cdc5L (cell division cycle 5-like) complex is a spliceosomal subcomplex that also plays a role in DNA repair. The complex contains the splicing factor hPrp19, also known as SNEV or hPso4, which is involved in cellular life-span regulation and proteasomal breakdown. In a recent large-scale proteomics analysis for proteins associated with this complex, proteins involved in transcription, cell-cycle regulation, ... [more]
Throughput
- Low Throughput
Additional Notes
- Sec6 (EXOC3) co-localizes with SNEVhPrp19/hPso4 in the nucleus upon LMB treatment
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| PRPF19 EXOC3 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - |
Curated By
- BioGRID