TAGLN
Gene Ontology Biological Process
Gene Ontology Molecular Function
PIK3CD
Gene Ontology Biological Process
- B cell activation [TAS]
- B cell chemotaxis [TAS]
- B cell receptor signaling pathway [TAS]
- Fc-epsilon receptor signaling pathway [TAS]
- T cell activation [TAS]
- T cell chemotaxis [TAS]
- T cell differentiation [TAS]
- T cell receptor signaling pathway [TAS]
- adaptive immune response [TAS]
- cytokine production [TAS]
- epidermal growth factor receptor signaling pathway [TAS]
- fibroblast growth factor receptor signaling pathway [TAS]
- inflammatory response [TAS]
- innate immune response [TAS]
- mast cell chemotaxis [TAS]
- mast cell degranulation [TAS]
- mast cell differentiation [TAS]
- natural killer cell activation [TAS]
- natural killer cell chemotaxis [TAS]
- natural killer cell differentiation [TAS]
- neurotrophin TRK receptor signaling pathway [TAS]
- neutrophil chemotaxis [TAS]
- neutrophil extravasation [TAS]
- phosphatidylinositol 3-kinase signaling [TAS]
- phosphatidylinositol biosynthetic process [TAS]
- phosphatidylinositol-3-phosphate biosynthetic process [NAS]
- phosphatidylinositol-mediated signaling [TAS]
- phospholipid metabolic process [TAS]
- protein phosphorylation [NAS]
- respiratory burst involved in defense response [TAS]
- signal transduction [NAS]
- small molecule metabolic process [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Reconstituted Complex
An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator.
Publication
Phosphorylation of Smooth Muscle 22α Facilitates Angiotensin II-Induced ROS Production Via Activation of the PKCδ-P47phox Axis Through Release of PKCδ and Actin Dynamics and Is Associated With Hypertrophy and Hyperplasia of Vascular Smooth Muscle Cells In Vitro and In Vivo.
Rationale: We have demonstrated that smooth muscle (SM) 22α inhibits cell proliferation via blocking Ras-ERK1/2 signaling in vascular smooth muscle cells (VSMCs) and in injured arteries. The recent study indicates that SM22α disruption can independently promote arterial inflammation through activation of reactive oxygen species (ROS)-mediated NF-κB pathways. However, the mechanisms by which SM22α controls ROS production have not been characterized. ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| TAGLN PIK3CD | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | 935550 |
Curated By
- BioGRID