BAIT
ASB12
RP11-284B18.4
ankyrin repeat and SOCS box containing 12
GO Process (0)
GO Function (0)
GO Component (0)
Homo sapiens
PREY
PFN2
D3S1319E, PFL
profilin 2
GO Process (8)
GO Function (4)
GO Component (1)
Gene Ontology Biological Process
- negative regulation of actin filament polymerization [IDA]
- negative regulation of epithelial cell migration [IMP]
- negative regulation of ruffle assembly [IMP]
- positive regulation of ATPase activity [IDA]
- positive regulation of actin filament bundle assembly [IMP]
- positive regulation of actin filament polymerization [IGI]
- positive regulation of peptidyl-serine phosphorylation [IMP]
- positive regulation of stress fiber assembly [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Protein interaction screening for the ankyrin repeats and suppressor of cytokine signaling (SOCS) box (ASB) family identify Asb11 as a novel endoplasmic reticulum resident ubiquitin ligase.
The ankyrin and SOCS (suppressor of cytokine signaling) box (ASB) family of proteins function as the substrate recognition subunit in a subset of Elongin-Cullin-SOCS (ECS) E3 ubiquitin ligases. Despite counting 18 members in humans, the identity of the physiological targets of the Asb proteins remains largely unexplored. To increase our understanding of the function of ASB proteins, we conducted a ... [more]
J. Biol. Chem. Jan. 24, 2014; 289(4);2043-54 [Pubmed: 24337577]
Throughput
- High Throughput
Curated By
- BioGRID