BAIT
ASB15
ankyrin repeat and SOCS box containing 15
GO Process (0)
GO Function (0)
GO Component (0)
Homo sapiens
PREY
MIF
GIF, GLIF, MMIF
macrophage migration inhibitory factor (glycosylation-inhibiting factor)
GO Process (21)
GO Function (7)
GO Component (6)
Gene Ontology Biological Process
- carboxylic acid metabolic process [IDA]
- cell proliferation [IDA]
- cell surface receptor signaling pathway [IDA]
- negative regulation of DNA damage response, signal transduction by p53 class mediator [IDA]
- negative regulation of apoptotic process [IDA]
- negative regulation of cell aging [IDA]
- negative regulation of cell cycle arrest [IDA]
- negative regulation of gene expression [IDA]
- negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [IDA]
- positive chemotaxis [IDA]
- positive regulation of B cell proliferation [IDA]
- positive regulation of ERK1 and ERK2 cascade [IDA]
- positive regulation of cytokine secretion [IDA]
- positive regulation of fibroblast proliferation [IDA]
- positive regulation of peptidyl-serine phosphorylation [IDA]
- positive regulation of peptidyl-tyrosine phosphorylation [IDA]
- positive regulation of phosphorylation [IDA]
- positive regulation of protein kinase A signaling [IDA]
- prostaglandin biosynthetic process [IDA]
- protein homotrimerization [IPI]
- regulation of macrophage activation [NAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Protein interaction screening for the ankyrin repeats and suppressor of cytokine signaling (SOCS) box (ASB) family identify Asb11 as a novel endoplasmic reticulum resident ubiquitin ligase.
The ankyrin and SOCS (suppressor of cytokine signaling) box (ASB) family of proteins function as the substrate recognition subunit in a subset of Elongin-Cullin-SOCS (ECS) E3 ubiquitin ligases. Despite counting 18 members in humans, the identity of the physiological targets of the Asb proteins remains largely unexplored. To increase our understanding of the function of ASB proteins, we conducted a ... [more]
J. Biol. Chem. Jan. 24, 2014; 289(4);2043-54 [Pubmed: 24337577]
Throughput
- High Throughput
Curated By
- BioGRID