BAIT
ATF7IP
AM, ATF-IP, MCAF, MCAF1, p621, RP11-502N13.4
activating transcription factor 7 interacting protein
GO Process (4)
GO Function (1)
GO Component (3)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Homo sapiens
PREY
PML
MYL, PP8675, RNF71, TRIM19
promyelocytic leukemia
GO Process (39)
GO Function (8)
GO Component (9)
Gene Ontology Biological Process
- DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest [ISS]
- PML body organization [IDA, IMP]
- apoptotic process [IDA]
- cell cycle arrest [IDA]
- cellular senescence [IDA]
- circadian regulation of gene expression [ISS]
- cytokine-mediated signaling pathway [TAS]
- endoplasmic reticulum calcium ion homeostasis [ISS]
- entrainment of circadian clock by photoperiod [ISS]
- innate immune response [IDA]
- interferon-gamma-mediated signaling pathway [TAS]
- intrinsic apoptotic signaling pathway in response to DNA damage [IDA]
- intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [ISS]
- maintenance of protein location in nucleus [IDA]
- negative regulation of angiogenesis [IMP]
- negative regulation of cell growth [IDA]
- negative regulation of cell proliferation [IMP]
- negative regulation of mitotic cell cycle [IDA]
- negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process [IMP]
- negative regulation of telomerase activity [IMP]
- negative regulation of telomere maintenance via telomerase [IMP]
- negative regulation of transcription, DNA-templated [IDA]
- negative regulation of translation in response to oxidative stress [IDA]
- negative regulation of viral release from host cell [IDA]
- positive regulation of apoptotic process involved in mammary gland involution [IDA]
- positive regulation of defense response to virus by host [IMP]
- positive regulation of extrinsic apoptotic signaling pathway [IMP]
- positive regulation of histone deacetylation [IDA]
- proteasome-mediated ubiquitin-dependent protein catabolic process [IDA]
- protein complex assembly [IDA]
- protein stabilization [IDA]
- protein targeting [IDA, IMP]
- regulation of calcium ion transport into cytosol [ISS]
- regulation of circadian rhythm [ISS]
- regulation of double-strand break repair [IMP]
- regulation of protein phosphorylation [ISS]
- regulation of transcription, DNA-templated [IMP]
- response to cytokine [IDA]
- response to hypoxia [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Co-localization
Interaction inferred from two proteins that co-localize in the cell by indirect immunofluorescence only when in addition, if one gene is deleted, the other protein becomes mis-localized. Also includes co-dependent association of proteins with promoter DNA in chromatin immunoprecipitation experiments.
Publication
The transcriptional cofactor MCAF1/ATF7IP is involved in histone gene expression and cellular senescence.
Cellular senescence is post-mitotic or oncogene-induced events combined with nuclear remodeling. MCAF1 (also known as hAM or ATF7IP), a transcriptional cofactor that is overexpressed in various cancers, functions in gene activation or repression, depending on interacting partners. In this study, we found that MCAF1 localizes to PML nuclear bodies in human fibroblasts and non-cancerous cells. Interestingly, depletion of MCAF1 in ... [more]
PLoS ONE Aug. 13, 2013; 8(7);e68478 [Pubmed: 23935871]
Throughput
- Low Throughput
Additional Notes
- MCAF1 localizes to PML bodies
Curated By
- BioGRID