BAIT
BCL2
AW986256, Bcl-2, C430015F12Rik, D630044D05Rik, D830018M01Rik
B cell leukemia/lymphoma 2
GO Process (135)
GO Function (13)
GO Component (14)
Gene Ontology Biological Process
- B cell differentiation [IMP]
- B cell homeostasis [IMP]
- B cell lineage commitment [IMP]
- B cell proliferation [ISO]
- B cell receptor signaling pathway [ISO]
- CD8-positive, alpha-beta T cell lineage commitment [IMP]
- T cell differentiation [IMP]
- T cell differentiation in thymus [IMP]
- T cell homeostasis [IGI, IMP]
- T cell lineage commitment [IMP]
- actin filament organization [IMP]
- apoptotic mitochondrial changes [IDA]
- apoptotic process [IMP, ISO]
- axon regeneration [IDA]
- axonogenesis [IMP]
- behavioral fear response [IMP]
- branching involved in ureteric bud morphogenesis [IDA, IGI]
- cell aging [IMP]
- cell growth [IMP]
- cell morphogenesis [IMP]
- cell proliferation [IGI]
- cellular calcium ion homeostasis [IDA]
- cellular response to DNA damage stimulus [ISO]
- cellular response to glucose starvation [IDA]
- cellular response to hypoxia [IDA]
- cellular response to organic substance [IDA]
- cochlear nucleus development [IMP]
- defense response to virus [ISO]
- developmental growth [IMP]
- developmental pigmentation [IGI, IMP]
- digestive tract morphogenesis [IMP]
- ear development [IGI, IMP]
- endoplasmic reticulum calcium ion homeostasis [IGI]
- extrinsic apoptotic signaling pathway in absence of ligand [IGI]
- extrinsic apoptotic signaling pathway via death domain receptors [ISO]
- focal adhesion assembly [IMP]
- gland morphogenesis [IMP]
- glomerulus development [IMP]
- growth [IMP]
- hair follicle morphogenesis [IMP]
- hemopoiesis [IMP]
- homeostasis of number of cells within a tissue [IMP]
- immune system development [IMP]
- intrinsic apoptotic signaling pathway in response to DNA damage [IBA]
- intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress [ISS]
- intrinsic apoptotic signaling pathway in response to oxidative stress [IMP]
- kidney development [IGI, IMP]
- leukocyte homeostasis [IMP]
- lymphocyte homeostasis [IGI, IMP]
- lymphoid progenitor cell differentiation [IMP]
- male gonad development [IGI]
- melanin metabolic process [IMP]
- melanocyte differentiation [IGI, IMP]
- mesenchymal cell development [IMP]
- metanephros development [IMP]
- negative regulation of G1/S transition of mitotic cell cycle [IDA, IMP]
- negative regulation of anoikis [ISO]
- negative regulation of apoptotic process [IDA, IGI, IMP, ISO, ISS]
- negative regulation of apoptotic signaling pathway [IDA, ISO]
- negative regulation of calcium ion transport into cytosol [IGI]
- negative regulation of cell growth [IMP]
- negative regulation of cell migration [IMP]
- negative regulation of cell proliferation [IMP]
- negative regulation of cellular pH reduction [ISO]
- negative regulation of extrinsic apoptotic signaling pathway in absence of ligand [ISO]
- negative regulation of intrinsic apoptotic signaling pathway [IBA, ISO]
- negative regulation of mitotic cell cycle [IDA]
- negative regulation of myeloid cell apoptotic process [IDA]
- negative regulation of neuron apoptotic process [IDA, IMP, ISO]
- negative regulation of ossification [IMP]
- negative regulation of osteoblast proliferation [IMP]
- negative regulation of retinal cell programmed cell death [IMP]
- neuron apoptotic process [IGI, IMP]
- oocyte development [IMP]
- organ growth [IMP]
- organ morphogenesis [IMP]
- ossification [IMP]
- ovarian follicle development [IMP]
- peptidyl-serine phosphorylation [IDA]
- peptidyl-threonine phosphorylation [IDA]
- pigment granule organization [IMP]
- pigmentation [IMP]
- positive regulation of B cell proliferation [ISO]
- positive regulation of catalytic activity [IMP]
- positive regulation of cell growth [ISO]
- positive regulation of cell proliferation [IDA]
- positive regulation of developmental pigmentation [IGI, IMP]
- positive regulation of melanocyte differentiation [IMP]
- positive regulation of multicellular organism growth [IMP]
- positive regulation of neuron maturation [IMP]
- positive regulation of peptidyl-serine phosphorylation [IGI]
- positive regulation of skeletal muscle fiber development [IMP]
- positive regulation of smooth muscle cell migration [IMP]
- post-embryonic development [IGI, IMP]
- protein dephosphorylation [IDA]
- protein polyubiquitination [ISO]
- reactive oxygen species metabolic process [IMP]
- regulation of apoptotic process [IGI]
- regulation of calcium ion transport [ISO]
- regulation of catalytic activity [IMP]
- regulation of cell cycle [IMP]
- regulation of cell-matrix adhesion [IMP]
- regulation of developmental pigmentation [IGI]
- regulation of gene expression [IMP]
- regulation of glycoprotein biosynthetic process [IMP]
- regulation of mitochondrial membrane permeability [IDA]
- regulation of mitochondrial membrane potential [IDA]
- regulation of nitrogen utilization [IGI]
- regulation of programmed cell death [IGI]
- regulation of protein heterodimerization activity [ISO]
- regulation of protein homodimerization activity [ISO]
- regulation of protein localization [IMP]
- regulation of protein stability [IMP]
- regulation of transmembrane transporter activity [ISO]
- regulation of viral genome replication [IDA]
- release of cytochrome c from mitochondria [IDA]
- renal system process [IMP]
- response to UV-B [IMP]
- response to acid chemical [IDA]
- response to cytokine [IMP, ISO]
- response to drug [IDA, ISO]
- response to gamma radiation [IMP]
- response to glucocorticoid [IDA, IMP]
- response to hydrogen peroxide [IMP]
- response to iron ion [ISO]
- response to ischemia [IMP]
- response to nicotine [ISO]
- response to oxidative stress [IMP]
- response to steroid hormone [IMP]
- response to toxic substance [IMP, ISO]
- single organismal cell-cell adhesion [IMP]
- spleen development [IGI, IMP]
- thymus development [IGI, IMP]
- transmembrane transport [ISO]
- ureteric bud development [IMP]
Gene Ontology Molecular Function- BH domain binding [ISO]
- BH3 domain binding [ISO]
- channel activity [ISO]
- channel inhibitor activity [ISO]
- identical protein binding [ISO]
- protease binding [ISO]
- protein binding [IPI]
- protein heterodimerization activity [IPI, ISO]
- protein homodimerization activity [IBA, ISO]
- protein phosphatase 2A binding [IDA]
- protein phosphatase binding [IDA]
- transcription factor binding [IPI]
- ubiquitin protein ligase binding [ISO]
- BH domain binding [ISO]
- BH3 domain binding [ISO]
- channel activity [ISO]
- channel inhibitor activity [ISO]
- identical protein binding [ISO]
- protease binding [ISO]
- protein binding [IPI]
- protein heterodimerization activity [IPI, ISO]
- protein homodimerization activity [IBA, ISO]
- protein phosphatase 2A binding [IDA]
- protein phosphatase binding [IDA]
- transcription factor binding [IPI]
- ubiquitin protein ligase binding [ISO]
Gene Ontology Cellular Component
- cell [IGI]
- cytoplasm [IDA, ISO]
- cytosol [IDA]
- endoplasmic reticulum [IDA, IGI, ISO]
- endoplasmic reticulum membrane [IDA]
- intracellular [IDA, IMP]
- membrane [IDA, ISO]
- mitochondrial membrane [IDA]
- mitochondrial outer membrane [IBA, ISO]
- mitochondrion [IDA, ISO]
- myelin sheath [IDA]
- nuclear membrane [IDA, ISO]
- nucleus [IDA, ISO]
- pore complex [ISO]
Mus musculus
PREY
CPT1A
C730027G07, CPTI, Cpt1
carnitine palmitoyltransferase 1a, liver
GO Process (9)
GO Function (2)
GO Component (7)
Gene Ontology Biological Process
- carnitine metabolic process [ISO]
- eating behavior [ISO]
- glucose metabolic process [ISO]
- long-chain fatty acid metabolic process [ISO]
- positive regulation of fatty acid beta-oxidation [ISO]
- protein homooligomerization [ISO]
- regulation of fatty acid oxidation [ISO]
- regulation of insulin secretion [ISO]
- triglyceride metabolic process [ISO]
Gene Ontology Molecular Function
Mus musculus
Reconstituted Complex
An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator.
Publication
Direct interaction of the mitochondrial membrane protein carnitine palmitoyltransferase I with Bcl-2.
To demonstrate interaction between the mitochondrial membrane proteins CPT I and Bcl-2 the yeast two-hybrid system was used. Full-length CPT I was required for binding to Bcl-2. Direct protein interaction was confirmed in a GST binding assay and in coimmunoprecipitations using two different kinds of anti-Bcl-2 antibodies. ... [more]
Biochem. Biophys. Res. Commun. Feb. 24, 1997; 231(3);523-5 [Pubmed: 9070836]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| CPT1A BCL2 | Two-hybrid Two-hybrid Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation. | Low | - | BioGRID | - |
Curated By
- BioGRID