BAIT
SREBF1
ADD-1, ADD1, SREBP-1, SREBP-1c, Srebp1
sterol regulatory element binding transcription factor 1
GO Process (31)
GO Function (10)
GO Component (6)
Gene Ontology Biological Process
- aging [IEP]
- cellular response to fatty acid [IEP]
- cellular response to insulin stimulus [IEP]
- cellular response to starvation [IDA, ISO]
- cholesterol metabolic process [IMP]
- insulin receptor signaling pathway [ISO]
- lipid biosynthetic process [ISO, ISS, TAS]
- lung development [IEP]
- negative regulation of insulin secretion [ISO]
- negative regulation of transcription from RNA polymerase II promoter [ISO]
- positive regulation of cholesterol biosynthetic process [ISO]
- positive regulation of histone deacetylation [ISO]
- positive regulation of transcription from RNA polymerase II promoter [IDA, ISO]
- positive regulation of transcription, DNA-templated [IMP, ISO]
- positive regulation of triglyceride biosynthetic process [ISO, ISS]
- regulation of fatty acid metabolic process [ISO]
- regulation of heart rate by chemical signal [ISO]
- regulation of insulin secretion [ISO]
- regulation of transcription, DNA-templated [ISO]
- response to cAMP [IEP]
- response to drug [IEP]
- response to fatty acid [IEP]
- response to food [IEP]
- response to glucagon [IEP]
- response to glucose [ISO]
- response to insulin [TAS]
- response to lipid [IEP]
- response to organic cyclic compound [IEP]
- response to peptide hormone [IEP]
- response to progesterone [IEP]
- response to retinoic acid [IEP]
Gene Ontology Molecular Function- DNA binding [ISO, ISS]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA]
- chromatin binding [IDA, ISO]
- protein complex binding [IPI]
- protein kinase binding [ISO]
- sequence-specific DNA binding [IDA, ISO]
- sequence-specific DNA binding transcription factor activity [ISO, ISS]
- sterol response element binding [ISO, ISS]
- transcription regulatory region DNA binding [ISO]
- DNA binding [ISO, ISS]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA]
- chromatin binding [IDA, ISO]
- protein complex binding [IPI]
- protein kinase binding [ISO]
- sequence-specific DNA binding [IDA, ISO]
- sequence-specific DNA binding transcription factor activity [ISO, ISS]
- sterol response element binding [ISO, ISS]
- transcription regulatory region DNA binding [ISO]
Gene Ontology Cellular Component
Rattus norvegicus
PREY
UBA52
D8Ertd21e, Gm1863, Rps27a, Ubb, Ubc
ubiquitin A-52 residue ribosomal protein fusion product 1
GO Process (0)
GO Function (0)
GO Component (1)
Gene Ontology Cellular Component
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
RNF20 regulates hepatic lipid metabolism through PKA-dependent SREBP1c degradation.
SREBP1c is a key transcription factor for de novo lipogenesis during the postprandial state. During nutritional deprivations, hepatic SREBP1c is rapidly suppressed by fasting signals to prevent lipogenic pathways. However, the molecular mechanisms that control SREBP1c turnover in response to fasting status are not thoroughly understood. To elucidate which factors are involved in the inactivation of SREBP1c, we attempted to ... [more]
Hepatology Jan. 15, 2014; 0(0); [Pubmed: 24425205]
Throughput
- Low Throughput
Curated By
- BioGRID