BAIT
LGR4
BNMD17, GPR48
leucine-rich repeat containing G protein-coupled receptor 4
GO Process (8)
GO Function (3)
GO Component (1)
Gene Ontology Biological Process
- bone mineralization [ISS]
- bone remodeling [ISS]
- circadian regulation of gene expression [ISS]
- negative regulation of cytokine secretion [ISS]
- negative regulation of toll-like receptor signaling pathway [ISS]
- osteoblast differentiation [ISS]
- positive regulation of canonical Wnt signaling pathway [IDA]
- spermatogenesis [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
MYCBP2
PAM, AC001226.5
MYC binding protein 2, E3 ubiquitin protein ligase
GO Process (0)
GO Function (1)
GO Component (1)
Gene Ontology Molecular Function
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
RSPO-LGR4 functions via IQGAP1 to potentiate Wnt signaling.
R-spondins (RSPOs) and their receptor leucine-rich repeat-containing G-protein coupled receptor 4 (LGR4) play pleiotropic roles in normal and cancer development as well as the survival of adult stem cells through potentiation of Wnt signaling. Current evidence indicates that RSPO-LGR4 functions to elevate levels of Wnt receptors through direct inhibition of two membrane-bound E3 ligases (RNF43 and ZNRF3), which otherwise ubiquitinate ... [more]
Proc. Natl. Acad. Sci. U.S.A. Apr. 01, 2014; 111(13);E1221-9 [Pubmed: 24639526]
Throughput
- High Throughput
Curated By
- BioGRID