BAIT
LGR4
BNMD17, GPR48
leucine-rich repeat containing G protein-coupled receptor 4
GO Process (8)
GO Function (3)
GO Component (1)
Gene Ontology Biological Process
- bone mineralization [ISS]
- bone remodeling [ISS]
- circadian regulation of gene expression [ISS]
- negative regulation of cytokine secretion [ISS]
- negative regulation of toll-like receptor signaling pathway [ISS]
- osteoblast differentiation [ISS]
- positive regulation of canonical Wnt signaling pathway [IDA]
- spermatogenesis [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
ATP2A2
ATP2B, DAR, DD, SERCA2
ATPase, Ca++ transporting, cardiac muscle, slow twitch 2
GO Process (17)
GO Function (7)
GO Component (10)
Gene Ontology Biological Process
- blood coagulation [TAS]
- calcium ion import into sarcoplasmic reticulum [IC, ISS]
- calcium ion transmembrane transport [IDA]
- calcium ion transport from cytosol to endoplasmic reticulum [IDA]
- cell adhesion [TAS]
- cellular calcium ion homeostasis [IDA]
- endoplasmic reticulum calcium ion homeostasis [IDA]
- epidermis development [TAS]
- ion transmembrane transport [TAS]
- positive regulation of endoplasmic reticulum calcium ion concentration [IDA]
- positive regulation of heart rate [TAS]
- regulation of cardiac muscle cell action potential involved in regulation of contraction [ISS]
- regulation of cardiac muscle cell membrane potential [IC, ISS, TAS]
- regulation of cardiac muscle contraction by calcium ion signaling [IDA]
- relaxation of cardiac muscle [IDA]
- sarcoplasmic reticulum calcium ion transport [TAS]
- transmembrane transport [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- calcium ion-transporting ATPase complex [IDA]
- endoplasmic reticulum [IDA]
- endoplasmic reticulum membrane [IDA, TAS]
- integral component of plasma membrane [TAS]
- intercalated disc [IDA]
- longitudinal sarcoplasmic reticulum [IDA]
- membrane [IDA]
- platelet dense tubular network membrane [TAS]
- sarcoplasmic reticulum [IDA]
- sarcoplasmic reticulum membrane [IC, TAS]
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
RSPO-LGR4 functions via IQGAP1 to potentiate Wnt signaling.
R-spondins (RSPOs) and their receptor leucine-rich repeat-containing G-protein coupled receptor 4 (LGR4) play pleiotropic roles in normal and cancer development as well as the survival of adult stem cells through potentiation of Wnt signaling. Current evidence indicates that RSPO-LGR4 functions to elevate levels of Wnt receptors through direct inhibition of two membrane-bound E3 ligases (RNF43 and ZNRF3), which otherwise ubiquitinate ... [more]
Proc. Natl. Acad. Sci. U.S.A. Apr. 01, 2014; 111(13);E1221-9 [Pubmed: 24639526]
Throughput
- High Throughput
Curated By
- BioGRID