PREY

LRPPRC

CLONE-23970, GP130, LRP130, LSFC
leucine-rich pentatricopeptide repeat containing
Homo sapiens

Affinity Capture-MS

An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.

Publication

RSPO-LGR4 functions via IQGAP1 to potentiate Wnt signaling.

Carmon KS, Gong X, Yi J, Thomas A, Liu Q

R-spondins (RSPOs) and their receptor leucine-rich repeat-containing G-protein coupled receptor 4 (LGR4) play pleiotropic roles in normal and cancer development as well as the survival of adult stem cells through potentiation of Wnt signaling. Current evidence indicates that RSPO-LGR4 functions to elevate levels of Wnt receptors through direct inhibition of two membrane-bound E3 ligases (RNF43 and ZNRF3), which otherwise ubiquitinate ... [more]

Proc. Natl. Acad. Sci. U.S.A. Apr. 01, 2014; 111(13);E1221-9 [Pubmed: 24639526]

Throughput

  • High Throughput

Curated By

  • BioGRID