BAIT
TGFB1
CED, DPD1, LAP, TGFB, TGFbeta
transforming growth factor, beta 1
GO Process (102)
GO Function (6)
GO Component (11)
Gene Ontology Biological Process
- ATP biosynthetic process [IDA]
- MAPK cascade [IMP]
- SMAD protein complex assembly [IDA]
- SMAD protein import into nucleus [IDA]
- SMAD protein signal transduction [IBA]
- active induction of host immune response by virus [TAS]
- blood coagulation [TAS]
- cell cycle arrest [IDA]
- cell-cell junction organization [IDA]
- cellular response to organic cyclic compound [IDA]
- cellular response to transforming growth factor beta stimulus [IDA]
- chondrocyte differentiation [IDA]
- common-partner SMAD protein phosphorylation [IDA]
- connective tissue replacement involved in inflammatory response wound healing [TAS]
- epidermal growth factor receptor signaling pathway [IDA]
- evasion or tolerance of host defenses by virus [IDA]
- extracellular matrix assembly [IDA]
- extracellular matrix organization [TAS]
- extrinsic apoptotic signaling pathway [IDA]
- hematopoietic progenitor cell differentiation [IDA]
- hyaluronan catabolic process [IDA]
- inflammatory response [IDA]
- lipopolysaccharide-mediated signaling pathway [IDA]
- lymph node development [ISS]
- macrophage derived foam cell differentiation [IC]
- mitotic cell cycle checkpoint [IDA]
- modulation by virus of host morphology or physiology [TAS]
- negative regulation of DNA replication [IMP]
- negative regulation of blood vessel endothelial cell migration [IDA]
- negative regulation of cell cycle [IDA]
- negative regulation of cell growth [IDA]
- negative regulation of cell proliferation [IDA]
- negative regulation of cell-cell adhesion [IDA]
- negative regulation of epithelial cell proliferation [IDA, IMP]
- negative regulation of extracellular matrix disassembly [IC]
- negative regulation of fat cell differentiation [IDA]
- negative regulation of gene expression [IDA]
- negative regulation of hyaluronan biosynthetic process [IDA]
- negative regulation of macrophage cytokine production [IDA]
- negative regulation of mitotic cell cycle [IDA]
- negative regulation of myoblast differentiation [IDA]
- negative regulation of protein phosphorylation [IDA]
- negative regulation of skeletal muscle tissue development [IDA]
- negative regulation of transcription, DNA-templated [IDA]
- negative regulation of transforming growth factor beta receptor signaling pathway [TAS]
- ossification involved in bone remodeling [IEP]
- pathway-restricted SMAD protein phosphorylation [IDA]
- phosphate-containing compound metabolic process [IDA]
- platelet activation [TAS]
- platelet degranulation [TAS]
- positive regulation of MAP kinase activity [IDA]
- positive regulation of NAD+ ADP-ribosyltransferase activity [IDA]
- positive regulation of SMAD protein import into nucleus [IDA]
- positive regulation of blood vessel endothelial cell migration [IDA]
- positive regulation of bone mineralization [IEP]
- positive regulation of cell migration [IDA]
- positive regulation of cell proliferation [IDA]
- positive regulation of cellular protein metabolic process [IDA]
- positive regulation of chemotaxis [IDA]
- positive regulation of collagen biosynthetic process [IDA, IMP]
- positive regulation of epithelial to mesenchymal transition [IDA, NAS]
- positive regulation of extracellular matrix assembly [IC]
- positive regulation of fibroblast migration [IDA]
- positive regulation of gene expression [IDA]
- positive regulation of interleukin-17 production [IDA]
- positive regulation of isotype switching to IgA isotypes [IDA]
- positive regulation of pathway-restricted SMAD protein phosphorylation [IDA]
- positive regulation of peptidyl-serine phosphorylation [IDA]
- positive regulation of peptidyl-threonine phosphorylation [IDA]
- positive regulation of phosphatidylinositol 3-kinase activity [IDA]
- positive regulation of protein complex assembly [IDA]
- positive regulation of protein dephosphorylation [IDA]
- positive regulation of protein import into nucleus [IDA]
- positive regulation of protein kinase B signaling [IDA]
- positive regulation of protein phosphorylation [IDA]
- positive regulation of protein secretion [IDA]
- positive regulation of superoxide anion generation [IDA]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
- positive regulation of transcription regulatory region DNA binding [IDA]
- positive regulation of transcription, DNA-templated [IDA, ISS]
- positive regulation vascular endothelial growth factor production [TAS]
- protein export from nucleus [IDA]
- protein import into nucleus, translocation [IDA]
- protein kinase B signaling [IMP]
- protein phosphorylation [ISS]
- receptor catabolic process [IDA]
- regulation of DNA binding [ISS]
- regulation of apoptotic process [IBA]
- regulation of binding [ISS]
- regulation of blood vessel remodeling [IC]
- regulation of cell migration [TAS]
- regulation of miRNA metabolic process [IDA]
- regulation of protein import into nucleus [ISS]
- regulation of striated muscle tissue development [ISS]
- regulation of transforming growth factor beta receptor signaling pathway [IDA]
- response to cholesterol [IDA]
- response to estradiol [IDA]
- response to progesterone [IDA]
- response to wounding [IEP]
- salivary gland morphogenesis [IEP]
- transforming growth factor beta receptor signaling pathway [IDA, TAS]
- viral life cycle [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
FKBP1A
FKBP-12, FKBP-1A, FKBP1, FKBP12, PKC12, PKCI2, PPIASE, RP11-314N13.2
FK506 binding protein 1A, 12kDa
GO Process (26)
GO Function (11)
GO Component (7)
Gene Ontology Biological Process
- 'de novo' protein folding [TAS]
- SMAD protein complex assembly [IDA]
- T cell activation [NAS]
- amyloid fibril formation [IDA]
- calcium ion transmembrane transport [NAS]
- chaperone-mediated protein folding [IBA]
- extracellular fibril organization [IDA]
- heart morphogenesis [ISS]
- heart trabecula formation [ISS]
- negative regulation of protein phosphatase type 2B activity [IDA]
- negative regulation of release of sequestered calcium ion into cytosol [IDA]
- negative regulation of ryanodine-sensitive calcium-release channel activity [IDA]
- positive regulation of I-kappaB kinase/NF-kappaB signaling [IMP]
- positive regulation of protein binding [IDA]
- positive regulation of protein ubiquitination [IDA]
- protein folding [NAS]
- protein maturation by protein folding [TAS]
- protein peptidyl-prolyl isomerization [IDA]
- protein refolding [TAS]
- regulation of activin receptor signaling pathway [IDA]
- regulation of amyloid precursor protein catabolic process [IGI]
- regulation of immune response [IMP]
- regulation of protein localization [IGI]
- regulation of ryanodine-sensitive calcium-release channel activity [IDA, ISS]
- transforming growth factor beta receptor signaling pathway [TAS]
- ventricular cardiac muscle tissue morphogenesis [ISS]
Gene Ontology Molecular Function- FK506 binding [IDA, NAS]
- SMAD binding [IPI]
- activin binding [IPI]
- calcium channel inhibitor activity [IDA]
- ion channel binding [ISS, TAS]
- macrolide binding [NAS]
- peptidyl-prolyl cis-trans isomerase activity [IDA, TAS]
- protein binding [IPI]
- signal transducer activity [IMP]
- transforming growth factor beta receptor binding [ISS, TAS]
- type I transforming growth factor beta receptor binding [ISS]
- FK506 binding [IDA, NAS]
- SMAD binding [IPI]
- activin binding [IPI]
- calcium channel inhibitor activity [IDA]
- ion channel binding [ISS, TAS]
- macrolide binding [NAS]
- peptidyl-prolyl cis-trans isomerase activity [IDA, TAS]
- protein binding [IPI]
- signal transducer activity [IMP]
- transforming growth factor beta receptor binding [ISS, TAS]
- type I transforming growth factor beta receptor binding [ISS]
Gene Ontology Cellular Component
Homo sapiens
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
Functional domains of androgen receptor coactivator p44/Mep50/WDR77and its interaction with Smad1.
p44/MEP50/WDR77 has been identified as a coactivator of androgen receptor (AR), with distinct growth suppression and promotion function in gender specific endocrine organs and their malignancies. We dissected the functional domains of p44 for protein interaction with transcription factors, transcriptional activation, as well as the functional domains in p44 related to its growth inhibition in prostate cancer. Using a yeast ... [more]
PLoS ONE Jun. 05, 2013; 8(5);e64663 [Pubmed: 23734213]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| TGFB1 FKBP1A | Two-hybrid Two-hybrid Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation. | Low | - | BioGRID | - |
Curated By
- BioGRID