AURKA
Gene Ontology Biological Process
- G2/M transition of mitotic cell cycle [TAS]
- anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process [TAS]
- mitotic cell cycle [TAS]
- mitotic nuclear division [TAS]
- mitotic spindle organization [IBA]
- negative regulation of protein binding [IDA]
- positive regulation of mitosis [TAS]
- protein autophosphorylation [TAS]
- protein phosphorylation [IDA]
- regulation of centrosome cycle [TAS]
- regulation of cytokinesis [IBA]
- regulation of protein stability [IMP]
- spindle stabilization [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- centrosome [IDA, TAS]
- chromosome passenger complex [IBA]
- condensed nuclear chromosome, centromeric region [IBA]
- cytosol [TAS]
- microtubule cytoskeleton [IDA]
- midbody [TAS]
- nucleus [IDA]
- perinuclear region of cytoplasm [IDA]
- spindle [TAS]
- spindle microtubule [IDA]
- spindle midzone [IBA]
- spindle pole centrosome [IDA]
SORL1
Gene Ontology Biological Process
- negative regulation of MAP kinase activity [ISS]
- negative regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process [IDA, IMP]
- negative regulation of beta-amyloid formation [IDA, IMP]
- negative regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process [IMP]
- negative regulation of neurofibrillary tangle assembly [ISS]
- negative regulation of neurogenesis [ISS]
- negative regulation of neuron death [ISS]
- negative regulation of protein binding [IDA]
- negative regulation of protein oligomerization [IMP]
- negative regulation of tau-protein kinase activity [ISS]
- positive regulation of ER to Golgi vesicle-mediated transport [IMP]
- positive regulation of choline O-acetyltransferase activity [ISS]
- positive regulation of early endosome to recycling endosome transport [IMP]
- positive regulation of endocytic recycling [IMP]
- positive regulation of protein catabolic process [IDA]
- positive regulation of protein exit from endoplasmic reticulum [IMP]
- positive regulation of protein localization to early endosome [IMP]
- post-Golgi vesicle-mediated transport [IDA]
- protein maturation [IDA]
- protein retention in Golgi apparatus [IDA]
- protein targeting [IDA, IMP]
- protein targeting to Golgi [IDA]
- protein targeting to lysosome [IDA]
- receptor-mediated endocytosis [TAS]
- regulation of smooth muscle cell migration [IDA]
- signal transduction [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- Golgi apparatus [IDA]
- Golgi cisterna [IDA]
- early endosome [IDA, IMP]
- endoplasmic reticulum [IDA]
- endosome [IDA]
- extracellular space [IDA]
- extracellular vesicular exosome [IDA]
- integral component of plasma membrane [TAS]
- membrane [IDA]
- nuclear envelope lumen [IDA]
- recycling endosome [IMP]
- trans-Golgi network [IDA]
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
LGALS3BP regulates centriole biogenesis and centrosome hypertrophy in cancer cells.
Centrosome morphology and number are frequently deregulated in cancer cells. Here, to identify factors that are functionally relevant for centrosome abnormalities in cancer cells, we established a protein-interaction network around 23 centrosomal and cell-cycle regulatory proteins, selecting the interacting proteins that are deregulated in cancer for further studies. One of these components, LGALS3BP, is a centriole- and basal body-associated protein ... [more]
Throughput
- High Throughput
Related interactions
Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
---|---|---|---|---|---|---|
AURKA SORL1 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | 0.999 | BioGRID | 1198116 | |
AURKA SORL1 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | 0.9923 | BioGRID | 2239916 | |
AURKA SORL1 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | 0.9886 | BioGRID | 3087158 |
Curated By
- BioGRID