PTC1
Gene Ontology Biological Process
- inactivation of MAPK activity involved in osmosensory signaling pathway [IDA, IGI, IMP]
- mitochondrion inheritance [IMP]
- pheromone-dependent signal transduction involved in conjugation with cellular fusion [IMP]
- protein dephosphorylation [IDA]
- tRNA splicing, via endonucleolytic cleavage and ligation [IMP]
Gene Ontology Molecular Function
PTC2
Gene Ontology Biological Process
Gene Ontology Molecular Function
Synthetic Growth Defect
A genetic interaction is inferred when mutations in separate genes, each of which alone causes a minimal phenotype, result in a significant growth defect under a given condition when combined in the same cell.
Publication
Effects of deletion of different PP2C protein phosphatase genes on stress responses in Saccharomyces cerevisiae.
A key mechanism of signal transduction in eukaryotes is reversible protein phosphorylation mediated through protein kinases and protein phosphatases (PPases). Modulation of signal transduction by this means regulates many biological processes. Saccharomyces cerevisiae has 40 PPases, including seven protein phosphatase 2C (PP2C PPase) genes (PTC1-PTC7). However, the precise functions remain poorly understood. To elucidate their cellular functions and to identify ... [more]
Throughput
- Low Throughput
Ontology Terms
- phenotype: vegetative growth (APO:0000106)
- phenotype: ionic stress resistance (APO:0000205)
Additional Notes
- Table 4
- ptc1 ptc2 double mutant is sensitive to NaCl
- ptc1 ptc2 ptc4 triple mutant is sensitive to NaCl (genetic complex)
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| PTC2 PTC1 | Negative Genetic Negative Genetic Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores. | High | -2.721 | BioGRID | 541010 | |
| PTC1 PTC2 | Negative Genetic Negative Genetic Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores. | High | -0.1258 | BioGRID | 365135 | |
| PTC2 PTC1 | Negative Genetic Negative Genetic Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores. | High | -0.1258 | BioGRID | 375493 | |
| PTC1 PTC2 | Negative Genetic Negative Genetic Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores. | High | -0.1278 | BioGRID | 2088570 | |
| PTC1 PTC2 | Negative Genetic Negative Genetic Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores. | High | -9.9923 | BioGRID | 323079 |
Curated By
- BioGRID