SRO7
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
SRO77
Gene Ontology Biological Process
Gene Ontology Cellular Component
Synthetic Growth Defect
A genetic interaction is inferred when mutations in separate genes, each of which alone causes a minimal phenotype, result in a significant growth defect under a given condition when combined in the same cell.
Publication
Sro7 and Sro77, the yeast homologues of the Drosophila lethal giant larvae (lgl), regulate cell proliferation via Rho1-Tor1 pathway.
The Saccharomyces cerevisiae Sro7 and Sro77 are homologues to the Drosophila tumor suppressor lethal giant larvae (lgl), which regulates cell polarity in Drosophila epithelial cells. We show that double mutation of SRO7/SRO77 is defective in colony growth. The colony of SRO7/SRO77 double deletion is much smaller than the wild type and appears to be round with a smooth surface, compared ... [more]
Throughput
- Low Throughput
Ontology Terms
- phenotype: vegetative growth (APO:0000106)
- phenotype: cold sensitivity (APO:0000148)
Additional Notes
- Figure 1
- sro7 sro77 double mutant is cold-sensitive
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| SRO7 SRO77 | Negative Genetic Negative Genetic Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores. | High | -6.5208 | BioGRID | 515652 | |
| SRO7 SRO77 | Negative Genetic Negative Genetic Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores. | High | -0.3609 | BioGRID | 2194528 | |
| SRO77 SRO7 | Negative Genetic Negative Genetic Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores. | High | -7.32 | BioGRID | 2355722 | |
| SRO77 SRO7 | Negative Genetic Negative Genetic Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores. | High | -15.8325 | BioGRID | 895850 | |
| SRO7 SRO77 | Phenotypic Enhancement Phenotypic Enhancement A genetic interaction is inferred when mutation or overexpression of one gene results in enhancement of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene. | Low | - | BioGRID | 156824 | |
| SRO7 SRO77 | Synthetic Growth Defect Synthetic Growth Defect A genetic interaction is inferred when mutations in separate genes, each of which alone causes a minimal phenotype, result in a significant growth defect under a given condition when combined in the same cell. | Low | - | BioGRID | 157409 | |
| SRO7 SRO77 | Synthetic Growth Defect Synthetic Growth Defect A genetic interaction is inferred when mutations in separate genes, each of which alone causes a minimal phenotype, result in a significant growth defect under a given condition when combined in the same cell. | Low | - | BioGRID | 511911 | |
| SRO7 SRO77 | Synthetic Growth Defect Synthetic Growth Defect A genetic interaction is inferred when mutations in separate genes, each of which alone causes a minimal phenotype, result in a significant growth defect under a given condition when combined in the same cell. | Low | - | BioGRID | 519345 |
Curated By
- BioGRID