BAIT

SRO7

SNI1, SOP1, L000003105, L000004193, YPR032W
Effector of Rab GTPase Sec4p; forms a complex with Sec4p and t-SNARE Sec9p; involved in exocytosis and docking and fusion of post-Golgi vesicles with plasma membrane; regulates cell proliferation and colony development via the Rho1-Tor1 pathway; homolog of Drosophila lgl tumor suppressor; SRO7 has a paralog, SRO77, that arose from the whole genome duplication
GO Process (4)
GO Function (2)
GO Component (3)

Gene Ontology Biological Process

Gene Ontology Molecular Function

Gene Ontology Cellular Component

Saccharomyces cerevisiae (S288c)
PREY

TUS1

SOP10, Rho family guanine nucleotide exchange factor TUS1, L000004619, L000004622, YLR425W
Guanine nucleotide exchange factor (GEF) that modulate Rho1p activity; involved in the cell integrity signaling pathway; interacts with Rgl1p; localization of Tus1p to the bed neck is regulated by Rgl1p; multicopy suppressor of tor2 mutation and ypk1 ypk2 double mutation; potential Cdc28p substrate
GO Process (2)
GO Function (1)
GO Component (2)

Gene Ontology Biological Process

Gene Ontology Molecular Function

Gene Ontology Cellular Component

Saccharomyces cerevisiae (S288c)

Dosage Rescue

A genetic interaction is inferred when over expression or increased dosage of one gene rescues the lethality or growth defect of a strain that is mutated or deleted for another gene.

Publication

Sro7 and Sro77, the yeast homologues of the Drosophila lethal giant larvae (lgl), regulate cell proliferation via Rho1-Tor1 pathway.

Liou LC, Ren Q, Gao Q, Zhang Z

The Saccharomyces cerevisiae Sro7 and Sro77 are homologues to the Drosophila tumor suppressor lethal giant larvae (lgl), which regulates cell polarity in Drosophila epithelial cells. We show that double mutation of SRO7/SRO77 is defective in colony growth. The colony of SRO7/SRO77 double deletion is much smaller than the wild type and appears to be round with a smooth surface, compared ... [more]

Microbiology (Reading, Engl.) Jul. 24, 2014; 0(0); [Pubmed: 25061043]

Throughput

  • Low Throughput

Ontology Terms

  • phenotype: vegetative growth (APO:0000106)

Additional Notes

  • Figure 5
  • TUS1 overexpression partially rescues growth defect of sro7 sro77 double mutant
  • genetic complex

Related interactions

InteractionExperimental Evidence CodeDatasetThroughputScoreCurated ByNotes
TUS1 SRO7
Negative Genetic
Negative Genetic

Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores.

High-2.9815BioGRID
901200

Curated By

  • BioGRID