COPS7A
Gene Ontology Biological Process
Gene Ontology Cellular Component
PTGS2
Gene Ontology Biological Process
- arachidonic acid metabolic process [TAS]
- cellular component movement [TAS]
- cellular response to hypoxia [IEP]
- cyclooxygenase pathway [IDA, TAS]
- lipoxygenase pathway [TAS]
- positive regulation of brown fat cell differentiation [ISS]
- positive regulation of cell migration involved in sprouting angiogenesis [ISS]
- positive regulation of fever generation [ISS]
- positive regulation of fibroblast growth factor production [ISS]
- positive regulation of nitric oxide biosynthetic process [ISS]
- positive regulation of platelet-derived growth factor production [ISS]
- positive regulation of prostaglandin biosynthetic process [NAS]
- positive regulation of transforming growth factor beta production [ISS]
- positive regulation vascular endothelial growth factor production [ISS]
- prostaglandin biosynthetic process [ISS, NAS]
- prostaglandin metabolic process [TAS]
- regulation of blood pressure [ISS]
- regulation of inflammatory response [NAS]
- small molecule metabolic process [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Reconstituted Complex
An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator.
Publication
The ubiquitin- and proteasome-dependent degradation of COX-2 is regulated by the COP9 signalosome and differentially influenced by coxibs.
The cyclooxygenase-2 (COX-2) enzyme is induced upon inflammation and in neoplastic tissues. It produces prostaglandins that stimulate tumor angiogenesis and tumor growth. Therefore, destruction and/or specific inhibition of COX-2 should be an important aspect of future tumor therapy. Recently, clinical application of specific COX-2 inhibitors called coxibs became doubtfully because they produce serious renal and cardiovascular complications under long term ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| COPS7A PTGS2 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | 425751 |
Curated By
- BioGRID