CD209
Gene Ontology Biological Process
- antigen processing and presentation [NAS]
- cell-cell recognition [TAS]
- heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [TAS]
- intracellular signal transduction [NAS]
- intracellular transport of virus [TAS]
- leukocyte cell-cell adhesion [NAS]
- modulation by virus of host morphology or physiology [TAS]
- peptide antigen transport [NAS]
- regulation of T cell proliferation [IDA]
- viral genome replication [NAS]
- virion attachment to host cell [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
HTR1B
Gene Ontology Biological Process
- G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger [TAS]
- adenylate cyclase-inhibiting serotonin receptor signaling pathway [IDA]
- cellular response to alkaloid [IDA]
- cellular response to drug [IDA]
- negative regulation of cAMP biosynthetic process [IDA]
- negative regulation of serotonin secretion [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
The BioPlex Network: A Systematic Exploration of the Human Interactome.
Protein interactions form a network whose structure drives cellular function and whose organization informs biological inquiry. Using high-throughput affinity-purification mass spectrometry, we identify interacting partners for 2,594 human proteins in HEK293T cells. The resulting network (BioPlex) contains 23,744 interactions among 7,668 proteins with 86% previously undocumented. BioPlex accurately depicts known complexes, attaining 80%-100% coverage for most CORUM complexes. The network ... [more]
Quantitative Score
- 0.981682943 [compPASS Score]
Throughput
- High Throughput
Additional Notes
- BioPlex 1.0 HEK 293T cells CompPASS score = 0.981682943, threshold = 0.75. Quantitative scores calculated by CompPASS-Plus (Huttlin et al. Cell, 2015, PMID: 26186194).
- See BioPlex Interactome for details (https://bioplex.hms.harvard.edu/index.php).
- This data has also been reanalyzed as part of BioPlex 2.0 (PMID: 28514442) and BioPlex 3.0 (PMID: 33961781). Only scores from within BioPlex 1.0 (PMID: 26186194) should be compared directly.
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| CD209 HTR1B | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | 0.9996 | BioGRID | 2229676 | |
| CD209 HTR1B | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | 0.9986 | BioGRID | 3049693 |
Curated By
- BioGRID