FAM63B
Gene Ontology Cellular Component
CYP2J2
Gene Ontology Biological Process
- arachidonic acid metabolic process [TAS]
- epoxygenase P450 pathway [IDA, TAS]
- exogenous drug catabolic process [IBA]
- icosanoid metabolic process [TAS]
- linoleic acid metabolic process [IDA]
- oxidation-reduction process [IBA]
- regulation of heart contraction [TAS]
- small molecule metabolic process [TAS]
- xenobiotic metabolic process [TAS]
Gene Ontology Molecular Function- arachidonic acid 11,12-epoxygenase activity [IDA]
- arachidonic acid 14,15-epoxygenase activity [IDA]
- arachidonic acid epoxygenase activity [IDA]
- heme binding [IBA]
- linoleic acid epoxygenase activity [IDA]
- oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen [IBA]
- oxygen binding [IBA]
- steroid hydroxylase activity [IBA]
- arachidonic acid 11,12-epoxygenase activity [IDA]
- arachidonic acid 14,15-epoxygenase activity [IDA]
- arachidonic acid epoxygenase activity [IDA]
- heme binding [IBA]
- linoleic acid epoxygenase activity [IDA]
- oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen [IBA]
- oxygen binding [IBA]
- steroid hydroxylase activity [IBA]
Gene Ontology Cellular Component
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
The BioPlex Network: A Systematic Exploration of the Human Interactome.
Protein interactions form a network whose structure drives cellular function and whose organization informs biological inquiry. Using high-throughput affinity-purification mass spectrometry, we identify interacting partners for 2,594 human proteins in HEK293T cells. The resulting network (BioPlex) contains 23,744 interactions among 7,668 proteins with 86% previously undocumented. BioPlex accurately depicts known complexes, attaining 80%-100% coverage for most CORUM complexes. The network ... [more]
Quantitative Score
- 0.999998451 [compPASS Score]
Throughput
- High Throughput
Additional Notes
- BioPlex 1.0 HEK 293T cells CompPASS score = 0.999998451, threshold = 0.75. Quantitative scores calculated by CompPASS-Plus (Huttlin et al. Cell, 2015, PMID: 26186194).
- See BioPlex Interactome for details (https://bioplex.hms.harvard.edu/index.php).
- This data has also been reanalyzed as part of BioPlex 2.0 (PMID: 28514442) and BioPlex 3.0 (PMID: 33961781). Only scores from within BioPlex 1.0 (PMID: 26186194) should be compared directly.
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| FAM63B CYP2J2 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | 1 | BioGRID | 2219084 | |
| FAM63B CYP2J2 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | 1 | BioGRID | 3143917 |
Curated By
- BioGRID