BAIT
HNRNPD
AUF1, AUF1A, HNRPD, P37, hnRNPD0
heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa)
GO Process (12)
GO Function (4)
GO Component (5)
Gene Ontology Biological Process
- RNA catabolic process [TAS]
- RNA metabolic process [TAS]
- RNA processing [TAS]
- RNA splicing [TAS]
- circadian regulation of translation [IMP]
- gene expression [TAS]
- mRNA metabolic process [TAS]
- mRNA splicing, via spliceosome [TAS]
- positive regulation of transcription, DNA-templated [NAS]
- positive regulation of translation [IMP]
- regulation of circadian rhythm [IMP]
- regulation of transcription, DNA-templated [NAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
PTGS2
COX-2, COX2, GRIPGHS, PGG/HS, PGHS-2, PHS-2, hCox-2
prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
GO Process (19)
GO Function (5)
GO Component (4)
Gene Ontology Biological Process
- arachidonic acid metabolic process [TAS]
- cellular component movement [TAS]
- cellular response to hypoxia [IEP]
- cyclooxygenase pathway [IDA, TAS]
- lipoxygenase pathway [TAS]
- positive regulation of brown fat cell differentiation [ISS]
- positive regulation of cell migration involved in sprouting angiogenesis [ISS]
- positive regulation of fever generation [ISS]
- positive regulation of fibroblast growth factor production [ISS]
- positive regulation of nitric oxide biosynthetic process [ISS]
- positive regulation of platelet-derived growth factor production [ISS]
- positive regulation of prostaglandin biosynthetic process [NAS]
- positive regulation of transforming growth factor beta production [ISS]
- positive regulation vascular endothelial growth factor production [ISS]
- prostaglandin biosynthetic process [ISS, NAS]
- prostaglandin metabolic process [TAS]
- regulation of blood pressure [ISS]
- regulation of inflammatory response [NAS]
- small molecule metabolic process [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-RNA
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and associated RNA species identified by Northern blot, RT-PCR, affinity labeling, sequencing, or microarray analysis.
Publication
Hsp70 is a novel posttranscriptional regulator of gene expression that binds and stabilizes selected mRNAs containing AU-rich elements.
The AU-rich elements (AREs) encoded within many mRNA 3' untranslated regions (3'UTRs) are targets for factors that control transcript longevity and translational efficiency. Hsp70, best known as a protein chaperone with well-defined peptide-refolding properties, is known to interact with ARE-like RNA substrates in vitro. Here, we show that cofactor-free preparations of Hsp70 form direct, high-affinity complexes with ARE substrates based ... [more]
Mol. Cell. Biol. Jan. 01, 2013; 33(1);71-84 [Pubmed: 23109422]
Throughput
- Low Throughput
Curated By
- BioGRID