PHO85
Gene Ontology Biological Process
- cellular response to DNA damage stimulus [IGI, IMP]
- fungal-type cell wall organization [IGI]
- negative regulation of calcium-mediated signaling [IGI]
- negative regulation of glycogen biosynthetic process [IMP]
- negative regulation of macroautophagy [IMP]
- negative regulation of phosphate metabolic process [IGI]
- negative regulation of sequence-specific DNA binding transcription factor activity [IGI, IMP]
- negative regulation of transcription from RNA polymerase II promoter [IGI]
- positive regulation of macroautophagy [IMP]
- protein phosphorylation [IDA]
- regulation of establishment or maintenance of cell polarity [IGI]
- regulation of protein localization [IDA]
- regulation of protein stability [IGI, IMP]
- regulation of transcription involved in G1/S transition of mitotic cell cycle [IGI, IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
GCN4
Gene Ontology Biological Process
- negative regulation of ribosomal protein gene transcription from RNA polymerase II promoter in response to nutrient levels [IMP]
- negative regulation of transcription from RNA polymerase II promoter [IMP]
- nitrogen catabolite activation of transcription from RNA polymerase II promoter [IMP]
- positive regulation of RNA polymerase II transcriptional preinitiation complex assembly [IDA, IGI, IMP]
- positive regulation of transcription initiation from RNA polymerase II promoter [IGI, IMP]
Gene Ontology Molecular Function- RNA polymerase II transcription factor binding transcription factor activity involved in negative regulation of transcription [IPI]
- RNA polymerase II transcription factor binding transcription factor activity involved in positive regulation of transcription [IDA, IMP, IPI]
- RNA polymerase II transcription factor recruiting transcription factor activity [IDA, IMP, IPI]
- TFIID-class binding transcription factor activity [IPI]
- chromatin binding [IDA]
- sequence-specific DNA binding [IDA]
- sequence-specific DNA binding transcription factor activity [IDA, IMP]
- RNA polymerase II transcription factor binding transcription factor activity involved in negative regulation of transcription [IPI]
- RNA polymerase II transcription factor binding transcription factor activity involved in positive regulation of transcription [IDA, IMP, IPI]
- RNA polymerase II transcription factor recruiting transcription factor activity [IDA, IMP, IPI]
- TFIID-class binding transcription factor activity [IPI]
- chromatin binding [IDA]
- sequence-specific DNA binding [IDA]
- sequence-specific DNA binding transcription factor activity [IDA, IMP]
Biochemical Activity (Phosphorylation)
An interaction is inferred from the biochemical effect of one protein upon another, for example, GTP-GDP exchange activity or phosphorylation of a substrate by a kinase. The bait protein executes the activity on the substrate hit protein. A Modification value is recorded for interactions of this type with the possible values Phosphorylation, Ubiquitination, Sumoylation, Dephosphorylation, Methylation, Prenylation, Acetylation, Deubiquitination, Proteolytic Processing, Glucosylation, Nedd(Rub1)ylation, Deacetylation, No Modification, Demethylation.
Publication
Regulation of the transcription factor Gcn4 by Pho85 cyclin PCL5.
The yeast transcription factor Gcn4 is regulated by amino acid starvation at the levels of both protein synthesis and stability. Gcn4 degradation depends on the ubiquitination complex SCF(CDC4) and requires phosphorylation by the cyclin-dependent kinase Pho85. Here, we show that Pcl5 is the Pho85 cyclin specifically required for Gcn4 degradation. PCL5 is itself induced by Gcn4 at the level of ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| PHO85 GCN4 | Biochemical Activity Biochemical Activity An interaction is inferred from the biochemical effect of one protein upon another, for example, GTP-GDP exchange activity or phosphorylation of a substrate by a kinase. The bait protein executes the activity on the substrate hit protein. A Modification value is recorded for interactions of this type with the possible values Phosphorylation, Ubiquitination, Sumoylation, Dephosphorylation, Methylation, Prenylation, Acetylation, Deubiquitination, Proteolytic Processing, Glucosylation, Nedd(Rub1)ylation, Deacetylation, No Modification, Demethylation. | Low | - | BioGRID | 330047 | |
| PHO85 GCN4 | Biochemical Activity Biochemical Activity An interaction is inferred from the biochemical effect of one protein upon another, for example, GTP-GDP exchange activity or phosphorylation of a substrate by a kinase. The bait protein executes the activity on the substrate hit protein. A Modification value is recorded for interactions of this type with the possible values Phosphorylation, Ubiquitination, Sumoylation, Dephosphorylation, Methylation, Prenylation, Acetylation, Deubiquitination, Proteolytic Processing, Glucosylation, Nedd(Rub1)ylation, Deacetylation, No Modification, Demethylation. | Low | - | BioGRID | 151408 | |
| PHO85 GCN4 | Dosage Lethality Dosage Lethality A genetic interaction is inferred when over expression or increased dosage of one gene causes lethality in a strain that is mutated or deleted for another gene. | High | - | BioGRID | 350224 | |
| GCN4 PHO85 | Synthetic Growth Defect Synthetic Growth Defect A genetic interaction is inferred when mutations in separate genes, each of which alone causes a minimal phenotype, result in a significant growth defect under a given condition when combined in the same cell. | Low | - | BioGRID | 637498 |
Curated By
- BioGRID