BAIT
SNW1
Bx42, NCOA-62, PRPF45, Prp45, SKIIP, SKIP
SNW domain containing 1
GO Process (19)
GO Function (9)
GO Component (7)
Gene Ontology Biological Process
- Notch signaling pathway [TAS]
- cellular response to retinoic acid [IDA]
- gene expression [TAS]
- intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [IMP]
- mRNA splicing, via spliceosome [IC, IDA]
- negative regulation of transcription from RNA polymerase II promoter [IDA]
- negative regulation of transcription, DNA-templated [IDA]
- positive regulation by host of viral transcription [IDA, IMP]
- positive regulation of histone H3-K4 methylation [IMP]
- positive regulation of mRNA splicing, via spliceosome [IMP]
- positive regulation of neurogenesis [ISS]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
- positive regulation of transforming growth factor beta receptor signaling pathway [IDA]
- positive regulation of vitamin D receptor signaling pathway [IDA]
- regulation of retinoic acid receptor signaling pathway [IDA]
- regulation of transcription from RNA polymerase II promoter [TAS]
- regulation of vitamin D receptor signaling pathway [IDA]
- retinoic acid receptor signaling pathway [IDA]
- transcription initiation from RNA polymerase II promoter [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
ARHGEF2
GEF, GEF-H1, GEFH1, LFP40, P40, RP11-336K24.3
Rho/Rac guanine nucleotide exchange factor (GEF) 2
GO Process (24)
GO Function (8)
GO Component (8)
Gene Ontology Biological Process
- actin filament organization [IMP]
- apoptotic signaling pathway [TAS]
- cell morphogenesis [IMP]
- cellular hyperosmotic response [ISS]
- cellular response to muramyl dipeptide [IDA]
- cellular response to tumor necrosis factor [ISS]
- intracellular protein transport [NAS]
- negative regulation of extrinsic apoptotic signaling pathway via death domain receptors [ISS]
- negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress [ISS]
- negative regulation of microtubule depolymerization [IMP]
- negative regulation of necroptotic process [ISS]
- neurotrophin TRK receptor signaling pathway [TAS]
- positive regulation of NF-kappaB transcription factor activity [IDA]
- positive regulation of Rac GTPase activity [IDA]
- positive regulation of Rho GTPase activity [IDA]
- positive regulation of apoptotic process [TAS]
- positive regulation of interleukin-6 production [IDA]
- positive regulation of peptidyl-tyrosine phosphorylation [IDA]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
- positive regulation of tumor necrosis factor production [IDA]
- regulation of Rho protein signal transduction [NAS]
- regulation of cell proliferation [TAS]
- regulation of small GTPase mediated signal transduction [TAS]
- small GTPase mediated signal transduction [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Direct interaction between hnRNP-M and CDC5L/PLRG1 proteins affects alternative splice site choice.
Heterogeneous nuclear ribonucleoprotein-M (hnRNP-M) is an abundant nuclear protein that binds to pre-mRNA and is a component of the spliceosome complex. A direct interaction was detected in vivo between hnRNP-M and the human spliceosome proteins cell division cycle 5-like (CDC5L) and pleiotropic regulator 1 (PLRG1) that was inhibited during the heat-shock stress response. A central region in hnRNP-M is required ... [more]
EMBO Rep. Jun. 01, 2010; 11(6);445-51 [Pubmed: 20467437]
Throughput
- High Throughput
Curated By
- BioGRID