BAIT

CDC5L

CDC5, CDC5-LIKE, CEF1, PCDC5RP, dJ319D22.1, RP1-319D22.1
cell division cycle 5-like
Homo sapiens

Affinity Capture-MS

An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.

Publication

Direct interaction between hnRNP-M and CDC5L/PLRG1 proteins affects alternative splice site choice.

Lleres D, Denegri M, Biggiogera M, Ajuh P, Lamond AI

Heterogeneous nuclear ribonucleoprotein-M (hnRNP-M) is an abundant nuclear protein that binds to pre-mRNA and is a component of the spliceosome complex. A direct interaction was detected in vivo between hnRNP-M and the human spliceosome proteins cell division cycle 5-like (CDC5L) and pleiotropic regulator 1 (PLRG1) that was inhibited during the heat-shock stress response. A central region in hnRNP-M is required ... [more]

EMBO Rep. Jun. 01, 2010; 11(6);445-51 [Pubmed: 20467437]

Throughput

  • High Throughput

Curated By

  • BioGRID